Seroatlas · Human Serome Atlas

MRS2

Magnesium transporter MRS2 homolog, mitochondrial

Also known as: MRS2_HUMAN, MRS2L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HD23
Gene: MRS2
Ensembl: ENSG00000124532
Chromosome: 6
Canonical length: 443 aa
Protein class: Predicted membrane proteins, Transporters
Quaternary structure: Homopentamer

OverviewNCBI Gene

Enables magnesium ion transmembrane transporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q9HD23|MRS2
     1  MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL
    61  RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF
   121  QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY
   181  PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS
   241  LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY
   301  RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG
   361  MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMMAS LPKKTLLADR
   421  SMELKNSLRL DGLGSGRSIL TNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 50 nTPM
tongue: 46 nTPM
heart muscle: 29 nTPM
retina: 28 nTPM
kidney: 23 nTPM
cerebellum: 21 nTPM

Single-cell type

myonuclei: 115 nCPM
parietal cells: 104 nCPM
megakaryocytes: 62 nCPM
cytotrophoblasts: 60 nCPM
choroid plexus epithelial cells: 55 nCPM
migrating cytotrophoblasts: 54 nCPM

Immune cell

myeloid DC: 25 nTPM
intermediate monocyte: 20 nTPM
non-classical monocyte: 19 nTPM
classical monocyte: 17 nTPM
NK-cell: 16 nTPM
MAIT T-cell: 15 nTPM

Brain region

cerebellum: 28 nTPM
choroid plexus: 25 nTPM
cerebral cortex: 19 nTPM
thalamus: 18 nTPM
hypothalamus: 18 nTPM
midbrain: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRS2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Leber-like hereditary optic neuropathy, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Magnesium transporter MRS2-like
Magnesium transporter MRS2-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRS2 as an antibody target. Whether an autoantibody or antibody against MRS2 could matter depends on whether native MRS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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