Seroatlas · Human Serome Atlas

MRRF

Ribosome-recycling factor, mitochondrial

Also known as: RRF, RRFM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96E11
Gene
MRRF
Ensembl
ENSG00000148187
Chromosome
9
Canonical length
262 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge

OverviewNCBI Gene

This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q96E11|MRRF
     1  MALGLKCFRM VHPTFRNYLA ASIRPVSEVT LKTVHERQHG HRQYMAYSAV PVRHFATKKA
    61  KAKGKGQSQT RVNINAALVE DIINLEEVNE EMKSVIEALK DNFNKTLNIR TSPGSLDKIA
   121  VVTADGKLAL NQISQISMKS PQLILVNMAS FPECTAAAIK AIRESGMNLN PEVEGTLIRV
   181  PIPQVTREHR EMLVKLAKQN TNKAKDSLRK VRTNSMNKLK KSKDTVSEDT IRLIEKQISQ
   241  MADDTVAELD RHLAVKTKEL LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRRF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 38 nTPM
  • tongue: 30 nTPM
  • rectum: 27 nTPM
  • heart muscle: 26 nTPM
  • esophagus: 24 nTPM
  • colon: 24 nTPM

Single-cell type

  • early spermatids: 295 nCPM
  • late spermatids: 281 nCPM
  • cardiomyocytes: 155 nCPM
  • myonuclei: 111 nCPM
  • choroid plexus epithelial cells: 101 nCPM
  • enterocytes: 100 nCPM

Immune cell

  • non-classical monocyte: 32 nTPM
  • myeloid DC: 30 nTPM
  • intermediate monocyte: 29 nTPM
  • NK-cell: 23 nTPM
  • classical monocyte: 18 nTPM
  • naive CD8 T-cell: 17 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebellum: 11 nTPM
  • thalamus: 11 nTPM
  • medulla oblongata: 11 nTPM
  • hypothalamus: 11 nTPM
  • white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribosome recycling factor
  • Ribosome recycling factor domain
  • RRF superfamily
  • Ribosome recycling factor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRRF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRRF as an antibody target. Whether an autoantibody or antibody against MRRF could matter depends on whether native MRRF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRRF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRRF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRRF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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