MRPS11

Protein identityUniProt · HPA

UniProt accession

P82912

Gene

MRPS11

Ensembl

ENSG00000181991

Chromosome

15

Canonical length

194 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>P82912|MRPS11
     1  MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF
    61  SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV SASNEPLAFA SCGTEGFRNA
   121  KKGTGIAAQT AGIAAAARAK QKGVIHIRVV VKGLGPGRLS AMHGLIMGGL EVISITDNTP
   181  IPHNGCRPRK ARKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.68

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-0.66

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• mitochondrial inner membrane
• mitochondrial small ribosomal subunit
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein uS11
• Small ribosomal subunit protein uS11, conserved site
• Small ribosomal subunit protein uS11 superfamily
• Ribosomal protein S11

KeywordsUniProt

• Mitochondrion
• Ribonucleoprotein
• Ribosomal protein
• Transit peptide