Seroatlas · Human Serome Atlas

MRPL55

Large ribosomal subunit protein mL55

Also known as: RM55_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7F7
Gene
MRPL55
Ensembl
ENSG00000162910
Chromosome
1
Canonical length
128 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q7Z7F7|MRPL55
     1  MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR LYPVLLVKQD
    61  GSTIHIRYRE PRRMLAMPID LDTLSPEERR ARLRKREAQL QSRKEYEQEL SDDLHVERYR
   121  QFWTRTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • liver: 91 nTPM
  • amygdala: 77 nTPM
  • cerebral cortex: 76 nTPM
  • skeletal muscle: 74 nTPM
  • heart muscle: 73 nTPM
  • basal ganglia: 72 nTPM

Single-cell type

  • late spermatids: 323 nCPM
  • hepatocytes: 320 nCPM
  • oocytes: 299 nCPM
  • gastric progenitor cells: 274 nCPM
  • epididymal principal cells: 232 nCPM
  • esophageal suprabasal cells: 176 nCPM

Immune cell

  • naive B-cell: 153 nTPM
  • plasmacytoid DC: 148 nTPM
  • T-reg: 129 nTPM
  • memory B-cell: 122 nTPM
  • intermediate monocyte: 114 nTPM
  • naive CD8 T-cell: 109 nTPM

Brain region

  • medulla oblongata: 53 nTPM
  • hypothalamus: 51 nTPM
  • cerebral cortex: 50 nTPM
  • cerebellum: 50 nTPM
  • white matter: 50 nTPM
  • thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0.01
gnomAD missense Z
0.77
DepMap mean gene effect
-0.51
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein mL55
  • Large ribosomal subunit protein mL55 superfamily
  • Mitochondrial ribosomal protein L55

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL55 as an antibody target. Whether an autoantibody or antibody against MRPL55 could matter depends on whether native MRPL55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL55. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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