Seroatlas · Human Serome Atlas

MRPL45

Large ribosomal subunit protein mL45

Also known as: RM45_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRJ2
Gene: MRPL45
Canonical length: 306 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MRPL45 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9BRJ2|MRPL45
     1  MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA
    61  RKAGLVIPPE KSDRSIHLAC TAGIFDAYVP PEGDARISSL SKEGLIERTE RMKKTMASQV
   121  SIRRIKDYDA NFKIKDFPEK AKDIFIEAHL CLNNSDHDRL HTLVTEHCFP DMTWDIKYKT
   181  VRWSFVESLE PSHVVQVRCS SMMNQGNVYG QITVRMHTRQ TLAIYDRFGR LMYGQEDVPK
   241  DVLEYVVFEK QLTNPYGSWR MHTKIVPPWA PPKQPILKTV MIPGPQLKPE EEYEEAQGEA
   301  QKPQLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 65 nTPM
pancreas: 39 nTPM
heart muscle: 34 nTPM
liver: 32 nTPM
stomach: 32 nTPM
kidney: 31 nTPM

Single-cell type

distal convoluted tubule cells: 33 nCPM
podocytes: 30 nCPM
proximal tubule cells: 29 nCPM
loop of henle epithelial cells: 27 nCPM
renal connecting tubule cells: 24 nCPM
renal collecting duct intercalated cells: 22 nCPM

Immune cell

myeloid DC: 11 nTPM
naive CD4 T-cell: 9.8 nTPM
NK-cell: 9.8 nTPM
intermediate monocyte: 8.2 nTPM
memory CD4 T-cell: 7.7 nTPM
memory B-cell: 7.6 nTPM

Brain region

basal ganglia: 1.6 nTPM
choroid plexus: 1.6 nTPM
cerebral cortex: 1.5 nTPM
midbrain: 1 nTPM
hypothalamus: 0.9 nTPM
pons: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.75
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tim44-like domain
NTF2-like domain superfamily
Tim44-like domain
Mitochondrial Large Ribosomal Subunit mL45

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL45 as an antibody target. Whether an autoantibody or antibody against MRPL45 could matter depends on whether native MRPL45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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