Seroatlas · Human Serome Atlas

MRPL36

Large ribosomal subunit protein bL36m

Also known as: L36mt, MRP-L36, PRPL36, RM36_HUMAN, RPMJ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0J6
Gene
MRPL36
Ensembl
ENSG00000171421
Chromosome
5
Canonical length
103 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nuclear bodies,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>Q9P0J6|MRPL36
     1  MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS LLSPGLLPHL
    61  LPALGFKNKT VLKKRCKDCY LVKRRGRWYV YCKTHPRHKQ RQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
135 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 135 nTPM
  • testis: 93 nTPM
  • tongue: 80 nTPM
  • heart muscle: 73 nTPM
  • liver: 72 nTPM
  • kidney: 62 nTPM

Single-cell type

  • late spermatids: 599 nCPM
  • late primary spermatocytes: 499 nCPM
  • early spermatids: 431 nCPM
  • esophageal basal cells: 221 nCPM
  • esophageal suprabasal cells: 203 nCPM
  • esophageal apical cells: 147 nCPM

Immune cell

  • plasmacytoid DC: 477 nTPM
  • T-reg: 144 nTPM
  • total PBMC: 142 nTPM
  • memory B-cell: 133 nTPM
  • myeloid DC: 128 nTPM
  • memory CD8 T-cell: 111 nTPM

Brain region

  • cerebellum: 36 nTPM
  • hypothalamus: 31 nTPM
  • pons: 31 nTPM
  • spinal cord: 31 nTPM
  • medulla oblongata: 31 nTPM
  • cerebral cortex: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.34
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein bL36
  • Large ribosomal subunit protein bL36 superfamily
  • Mitochondrial Large Ribosomal Subunit bL36m
  • Ribosomal protein L36

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL36 as an antibody target. Whether an autoantibody or antibody against MRPL36 could matter depends on whether native MRPL36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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