MRPL34
Large ribosomal subunit protein bL34m
Also known as: L34mt, MGC24974, MGC2633, RM34_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQ48
- Gene
- MRPL34
- Ensembl
- ENSG00000130312
- Chromosome
- 19
- Canonical length
- 92 aa
- Protein class
- Predicted intracellular proteins, Ribosomal proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
92 residues, UniProt reviewed canonical sequence.
>Q9BQ48|MRPL34
1 MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG NEYQPSNIKR
61 KNKHGWVRRL STPAGVQVIL RRMLKGRKSL SHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MRPL34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 212 nTPM
Expression across tissuesHPA
Tissue
- liver: 212 nTPM
- skeletal muscle: 199 nTPM
- heart muscle: 187 nTPM
- kidney: 160 nTPM
- tongue: 130 nTPM
- adrenal gland: 121 nTPM
Single-cell type
- late primary spermatocytes: 448 nCPM
- hepatocytes: 323 nCPM
- hofbauer cells: 221 nCPM
- esophageal basal cells: 211 nCPM
- enterocytes: 196 nCPM
- parietal cells: 195 nCPM
Immune cell
- total PBMC: 277 nTPM
- plasmacytoid DC: 234 nTPM
- naive B-cell: 212 nTPM
- T-reg: 212 nTPM
- memory B-cell: 205 nTPM
- memory CD4 T-cell: 204 nTPM
Brain region
- choroid plexus: 136 nTPM
- thalamus: 82 nTPM
- hypothalamus: 78 nTPM
- cerebellum: 77 nTPM
- cerebral cortex: 74 nTPM
- basal ganglia: 72 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- -0.84
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Large ribosomal subunit protein bL34
- Ribosomal protein L34
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MRPL34 as an antibody target. Whether an autoantibody or antibody against MRPL34 could matter depends on whether native MRPL34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MRPL34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MRPL34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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