Seroatlas · Human Serome Atlas

MRPL30

Large ribosomal subunit protein uL30m

Also known as: MRP-L28, RM30_HUMAN, RPML28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TCC3
Gene
MRPL30
Ensembl
ENSG00000185414
Chromosome
2
Canonical length
161 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q8TCC3|MRPL30
     1  MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP
    61  QNPHKLHIVT RIKSTRRRPY WEKDIIKMLG LEKAHTPQVH KNIPSVNAKL KVVKHLIRIK
   121  PLKLPQGLPA EENMSNTCLK STGELVVQWH LKPVEQKAHE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 20 nTPM
  • skeletal muscle: 12 nTPM
  • liver: 8.4 nTPM
  • heart muscle: 8.3 nTPM
  • kidney: 8.3 nTPM
  • breast: 7.8 nTPM

Single-cell type

  • megakaryocytes: 12 nCPM
  • fallopian secretory cells: 12 nCPM
  • erythrocyte progenitors: 11 nCPM
  • megakaryocyte progenitors: 11 nCPM
  • megakaryocyte-erythroid progenitors: 10 nCPM
  • endometrial stromal cells: 9.9 nCPM

Immune cell

  • memory CD8 T-cell: 5 nTPM
  • intermediate monocyte: 4.8 nTPM
  • classical monocyte: 4.6 nTPM
  • memory B-cell: 4.6 nTPM
  • T-reg: 4.3 nTPM
  • naive B-cell: 4.1 nTPM

Brain region

  • cerebellum: 14 nTPM
  • cerebral cortex: 13 nTPM
  • hypothalamus: 13 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 13 nTPM
  • hippocampal formation: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.05
gnomAD missense Z
0.43
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL30 as an antibody target. Whether an autoantibody or antibody against MRPL30 could matter depends on whether native MRPL30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPL30. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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