Seroatlas · Human Serome Atlas

MROH9

Maestro heat-like repeat-containing protein family member 9

Also known as: ARMC11, C1orf129, FLJ23550, MROH9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TGP6
Gene: MROH9
Ensembl: ENSG00000117501
Chromosome: 1
Canonical length: 573 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MROH9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q5TGP6|MROH9
     1  MLTRNPKTKS SLQILQDSVK WHHMAHKVNS LLDAYSGLLS NESMILAVNS SFVDPLLQFE
    61  SQLKIIESSF GMLVVMPSLD KVKEMGSSYE YIEDMENLYH NILNIYENIL TSLVSKDLYK
   121  LQILKEMLVW MSKDSSYLQE RIMVIINKVL RFTVTKVRKY ISVDAPCLGL LAAELSLLCS
   181  HEDPSIVKQA SLGMCHLLYI ARCQNDIGTN KPTNGKSHSL QFPSSDVEFL PKEFQQDESK
   241  IAQRVGQTLL PPLLTDFVQS LLMKLSSPDD KIASDAASIL IFTLEFHAEK VTMVSKIVDA
   301  IYRQLCDNNC MKDVMLQVIT LLTCTSPKKV IFQLMDYPVP ADDTLIQMWK AACSQASVAP
   361  HVLKTILLIL KGKPGEMEDT VTEGKRFSLD ITNLMPLAAC QALCTFLPLG SYRKAVAQYF
   421  PQLLTTLMFQ VFYNSELKPI LKDRALYAQD ALRVLLNCSG LQQVDITLMK ENFWDQLSED
   481  LCYYHGVCFI AKTLSEYNFP QFPETLSYLY KLSVEGPRRS EDTVIVLIFL TEVSFVDCEQ
   541  LCSHFLFLPK FKSKFQFLVS LPLNVGSYQD LRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MROH9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 2.4 nTPM
testis: 1.5 nTPM
lung: 0.8 nTPM
cervix: 0.1 nTPM
endometrium: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

respiratory ciliated cells: 386 nCPM
endometrial ciliated cells: 170 nCPM
fibro-adipogenic progenitors: 87 nCPM
oligodendrocyte progenitor cells: 87 nCPM
fallopian tube ciliated cells: 78 nCPM
late primary spermatocytes: 76 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 3.7 nTPM
medulla oblongata: 3 nTPM
pons: 2.7 nTPM
thalamus: 2.7 nTPM
white matter: 2.4 nTPM
spinal cord: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MROH9 as an antibody target. Whether an autoantibody or antibody against MROH9 could matter depends on whether native MROH9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MROH9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MROH9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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