MROH8
Protein MROH8
Also known as: MROH8_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- Q9H579
- Gene
- MROH8
- Canonical length
- 483 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for MROH8 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
483 residues, UniProt reviewed canonical sequence.
>Q9H579|MROH8
1 MSSKHRICSQ EEVVIPCAYD SDSESVDLEL SNLEIIKKGS SSIELTDLDI PDIPGLHCEP
61 LSHSPRHLTQ QDPLSEAIVE KLIQSIQKVF NGELKGELEK LKFLGDLSSL SQALPYDETA
121 KSFIHSHIAD IVHTLNVLVQ EERPHSLSSS MRQEVFVTIA DLSYQDVHLL LGSEDRAELF
181 SLTIKSIITL PSVRTLTQIQ EIMPNGTCNT ECLYRQTFQA FSEMLQSLVV KDPHLENLDT
241 IIKLPLRFQR LGHLVALMAL LCGDPQEKVA EEAAEGIHSL LHITLRLKYI THDKKDQQNL
301 KRALTKCREF LELHSSAAKC FYNCPFRIAQ VFEGFLDSNE LCQFIMTTFD TLKTLKHPCI
361 QRSAGELLLT LAKNTESQFE KVPEIMGVIC AQLSIISQPR VRQQIINTVS LFISRPKYTD
421 IVLSFLLCHP VPYNRHLAEV WRMLSVELPS TTWILWRLLR KLQKCHNEPA QEKMAYVAVA
481 VSPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MROH8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- testis: 17 nTPM
- skeletal muscle: 5.4 nTPM
- tongue: 4 nTPM
- retina: 3.7 nTPM
- epididymis: 3.3 nTPM
- choroid plexus: 2.7 nTPM
Single-cell type
- retinal ganglion cells: 97 nCPM
- breast myoepithelial cells: 72 nCPM
- myonuclei: 68 nCPM
- sertoli cells: 63 nCPM
- late primary spermatocytes: 57 nCPM
- epididymal principal cells: 51 nCPM
Immune cell
- plasmacytoid DC: 2.2 nTPM
- memory B-cell: 1 nTPM
- MAIT T-cell: 0.9 nTPM
- naive B-cell: 0.7 nTPM
- gdT-cell: 0.6 nTPM
- intermediate monocyte: 0.6 nTPM
Brain region
- cerebellum: 6.3 nTPM
- hypothalamus: 5.9 nTPM
- cerebral cortex: 5.4 nTPM
- midbrain: 5.3 nTPM
- thalamus: 5 nTPM
- spinal cord: 4.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.85
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.73
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MROH8 as an antibody target. Whether an autoantibody or antibody against MROH8 could matter depends on whether native MROH8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MROH8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MROH8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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