Seroatlas · Human Serome Atlas

MROH7

Maestro heat-like repeat-containing protein family member 7

Also known as: C1orf175, FLJ46354, HEATR8, MROH7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CQ1
Gene: MROH7
Ensembl: ENSG00000184313
Chromosome: 1
Canonical length: 1323 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1323 residues, UniProt reviewed canonical sequence.

>Q68CQ1|MROH7
     1  MALSPGANLV FHEDPKMTPS PPSCGAPGLG SGTIPQPHPD MAQVPMLNLL PSPGLALVPD
    61  LNDSLSPVSG EASGLVSENT PRPDDSRAIA PASLQITSSC SGEALDLDSK DVSRPDSQGR
   121  LCPASNPILS PSSTEAPRLS SGNHPQSNSE DAFKCLSSKI FKLGQRNSNP SRHELNPFIR
   181  HHSREGLVLG HCISRPSSKA LLIPTSNSSL DLDSNPLLNM GSRNTSKLNL NVAPDSHGTL
   241  IPDTNETITL ASHNISESVS KGAFSTTWST SSKETMNVAS SGHSRSDLSV TITQASYVTL
   301  IPGSSYGISL HSSTHEPNST ISPPSCMTLI LGSNETLSLD SSLLFSDTST LTLSSQQDDA
   361  KDNSIHTVPL EENLESWSEM ASIKVGQFPL GFPISNPAGK DAVTLQGIPE GAFDEVTSCL
   421  VKVPEKTEGG NNMALVENVT TLQKSQDLLE AEGEKKTMIK KIMRQIQEEP LDSLSSSVRK
   481  QAMEILTQLS HTQPTLGMRE RSELVNVCVH SVFSLPSVQA MQEKDEAKAE TIQALYHQTL
   541  EALQTLLKAL FIEDPTPAGL KSILEALGPW MNSGKAHERA RAVNTNVSVL NHMLLTLPFF
   601  MPLGFPALGL LLGRLILHIG DPDEEIGCEA LDGIIILYTI LELQKRARDK EETNKKELYE
   661  SNKHFLGPYN PVSPCQNILR VIEEFGDFLG PQQIKDLLLA ALEGLKGSSE APGKDSREMM
   721  QLASEVMLSS VLEWYRHRAL EVIPEIMQGI YMQLSHIQEP RARQVALLPV SLLASSFMTE
   781  VVVALLMCPL PLNSNGAEMW RQLILCKPSC DVRDLLDLLL GSLKEKPVTK EGRASIVPLA
   841  AASGLCELLS VNSCMGRVRR IYPQLLLALL IQVHYHIGLN LPGCVAPPKD TKKGAQPSPF
   901  VPVRWVVKVV KTLLLRMGCS YETTFLEDQG GWELMEQVES HHRGVALLAR AMVQYSCQEL
   961  CRILYLLIPL LERGDEKHRI TATAFFVELL QMEQVRRIPE EYSLGRMAEG LSHHDPIMKV
  1021  LSIRGLVILA RRSEKTAKVK ALLPSMVKGL KNMDGMLVVE AVHNLKAVFK GRDQKLMDSA
  1081  VYVEMLQILL PHFSDAREVV RSSCINLYGK VVQKLRAPRT QAMEEQLVST LVPLLLTMQE
  1141  GNSKVSQKCV KTLLRCSYFM AWELPKRAYS RKPWDNQQQT VAKICKCLVN THRDSAFIFL
  1201  SQSLEYAKNS RASLRKCSVM FIGSLVPCME SIMTEDRLNE VKAALDNLRH DPEASVCIYA
  1261  AQVQDHILAS CWQNSWLPHG NSWVCYSATT HRWSPSCENL PTSHQRRSWI MQALGSWKMS
  1321  LKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MROH7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

testis: 51 nTPM
choroid plexus: 9.5 nTPM
thyroid gland: 3.9 nTPM
pituitary gland: 2.9 nTPM
heart muscle: 2.4 nTPM
kidney: 2.2 nTPM

Single-cell type

late spermatids: 490 nCPM
early spermatids: 91 nCPM
late primary spermatocytes: 30 nCPM
tuft cells: 12 nCPM
sertoli cells: 4.8 nCPM
astrocytes: 4.7 nCPM

Immune cell

eosinophil: 0.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 13 nTPM
thalamus: 5.5 nTPM
midbrain: 5.4 nTPM
medulla oblongata: 5.2 nTPM
cerebellum: 4.9 nTPM
cerebral cortex: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: -0.08
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MROH7 as an antibody target. Whether an autoantibody or antibody against MROH7 could matter depends on whether native MROH7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MROH7 is annotated as secreted, so native MROH7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MROH7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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