Seroatlas · Human Serome Atlas

MROH6

Maestro heat-like repeat-containing protein family member 6

Also known as: C8orf73, MROH6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGR9
Gene: MROH6
Ensembl: ENSG00000204839
Chromosome: 8
Canonical length: 719 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>A6NGR9|MROH6
     1  MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA
    61  LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL
   121  EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL
   181  ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA
   241  ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH
   301  ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG
   361  LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL
   421  GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA
   481  ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH
   541  DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL
   601  SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA
   661  AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MROH6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

esophagus: 23 nTPM
skin: 14 nTPM
cervix: 9.4 nTPM
cerebellum: 9 nTPM
vagina: 8.2 nTPM
liver: 7.3 nTPM

Single-cell type

papillary tip epithelial cells: 7.8 nCPM
renal collecting duct principal cells: 7.8 nCPM
proximal tubule cells: 5.4 nCPM
loop of henle epithelial cells: 3.1 nCPM
astrocytes: 2.6 nCPM
renal collecting duct intercalated cells: 2.3 nCPM

Immune cell

classical monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 1.7 nTPM
thalamus: 1.5 nTPM
midbrain: 1.4 nTPM
basal ganglia: 1.3 nTPM
cerebellum: 1.3 nTPM
hippocampal formation: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.66
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MROH6 as an antibody target. Whether an autoantibody or antibody against MROH6 could matter depends on whether native MROH6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MROH6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MROH6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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