Seroatlas · Human Serome Atlas

MROH5

Maestro heat-like repeat family member 5

Also known as: MROH5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUA9
Gene: MROH5
Canonical length: 1318 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for MROH5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1318 residues, UniProt reviewed canonical sequence.

>Q6ZUA9|MROH5
     1  MDRQCSERPY SCTPTGRVSS AVSQNSRISP PVSTSMKDSS CMKVHQDSAR RDRWSHPTTI
    61  LLHKSQSSQA TLMLQEHRMF MGEAYSAATG FKMLQDMNSA DPFHLKYIIK KIKNMAHGSP
   121  KLVMETIHDY FIDNPEISSR HKFRLFQTLE MVIGASDVLE ETWEKTFTRL ALENMTKATE
   181  LEDIYQDAAS NMLVAICRHS WRVVAQHLET ELLTGVFPHR SLLYVMGVLS SSEELFSQED
   241  KACWEEQLIQ MAIKSVPFLS TDVWSKELLW TLTTPSWTQQ EQSPEKAFLF TYYGLILQAE
   301  KNGATVRRHL QALLETSHQW PKQREGMALT LGLAATRHLD DVWAVLDQFG RSRPIRWSLP
   361  SSSPKNSEDL RWKWASSTIL LAYGQVAAKA RAHILPWVDN IVSRMVFYFH YSSWDETLKQ
   421  SFLTATLMLM GAVSRSEGAH SYEFFQTSEL LQCLMVLMEK EPQDTLCTRS RQQAMHIASS
   481  LCKLRPPIDL ERKSQLLSTC FRSVFALPLL DALEKHTCLF LEPPNIQLWP VARERAGWTH
   541  QGWGPRAVLH CSEHLQSLYS RTMEALDFML QSLIMQNPTA DELHFLLSHL YIWLASEKAH
   601  ERQRAVHSCM ILLKFLNHNG YLDPKEDFKR IGQLVGILGM LCQDPDRATQ RCSLEGASHL
   661  YQLLMCHKTG EALQAESQAP KELSQAHSDG APLWNSRDQK ATPLGPQEMA KNHIFQLCSF
   721  QVIKDIMQQL TLAELSDLIW TAIDGLGSTS PFRVQAASEM LLTAVQEHGA KLEIVSSMAQ
   781  AIRLRLCSVH IPQAKEKTLH AITLLARSHT CELVATFLNI SIPLDSHTFQ LWRALGAGQP
   841  TSHLVLTTLL ACLQERPLPT GASDSSPCPK EKTYLRLLAA MNMLHELQFA REFKQAVQEG
   901  YPKLFLALLT QMHYVLELNL PSEPQPKQQA QEAAVPSPQS CSTSLEALKS LLSTTGHWHD
   961  FAHLELQGSW ELFTTIHTYP KGVGLLARAM VQNHCRQIPA VLRQLLPSLQ SPQERERKVA
  1021  ILILTKFLYS PVLLEVLPKQ AALTVLAQGL HDPSPEVRVL SLQGLSNILF HPDKGSLLQG
  1081  QLRPLLDGFF QSSDQVIVCI MGTVSDTLHR LGAQGTGSQS LGVAISTRSF FNDERDGIRA
  1141  AAMALFGDLV AAMADRELSG LRTQVHQSMV PLLLHLKDQC PAVATQAKFT FYRCAVLLRW
  1201  RLLHTLFCTL AWERGLSARH FLWTCLMTRS QEEFSIHLSQ ALSYLHSHSC HIKTWVTLFI
  1261  GHTICYHPQA VFQMLNAVDT NLLFRTFEHL RSDPEPSIRE FATSQLSFLQ KVSARPKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MROH5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

testis: 1.5 nTPM
small intestine: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM

Single-cell type

late spermatids: 204 nCPM
early spermatids: 144 nCPM
late primary spermatocytes: 47 nCPM
parietal cells: 1.8 nCPM
gastric chief cells: 1.1 nCPM
leydig cells: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.3 nTPM
cerebral cortex: 0.2 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0.01
gnomAD missense Z: -0.19

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MROH5 as an antibody target. Whether an autoantibody or antibody against MROH5 could matter depends on whether native MROH5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MROH5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MROH5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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