Seroatlas · Human Serome Atlas

MROH2A

Maestro heat-like repeat-containing protein family member 2A

Also known as: HEATR7B1, MRO2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NES4
Gene
MROH2A
Ensembl
ENSG00000185038
Chromosome
2
Canonical length
1674 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a HEAT-domain-containing protein. The function of the encoded protein has not been characterized. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

1674 residues, UniProt reviewed canonical sequence.

>A6NES4|MROH2A
     1  MTEAITEAAV ASSEEVSEER DDLGPLELHD SGTFQQVVNL LDIIDSESAK TDTTGAGLDM
    61  RKTLASVIIM EKATTEPSVV INTLIRCLQV PEISTQRKVN IYNILQDIIQ QEGELEEQCV
   121  QRLVAIASKE MREIPEMEGY MKAEVASDTL VALSRNHFSL VMYELQHHLK PLNLTDEFVI
   181  ITLAKLANGN VFEFMPYMGI TLATIFTMLR LANEAKIRQA ICSAMETFCE TVQFYLKHLE
   241  ESVYPVMTEE EFALKVFPMY RYFVTVWLRH YNPEVKLGVI KSLKPMLGLL LPNDDLREQV
   301  YDYIPLLLAE YQGSLEVLFV TQVLRQILEL SVTTNTPVPQ MQLHTIFTEL HVQVCNKAPA
   361  QHQYSSQNLM EMVHCFVALA RSYPKELMKF FFSQMETNKE AVRVGTLNLI RAIVSADEPR
   421  MSIRAIYLAI RVVKNTISDT RSKVRMAILH IIGQLALCGY QERIKGWGLK YLSVQLTLST
   481  YKLTNRREKF YQRDLEERMV HKVTMDTVKI ITSSVSGMTT EFWVRLLCYI METDYVEALT
   541  PICISLTNLA EHQLHGQDVD VSVAGKSRQV DLPAPQKLLA RLLVLMSSPY KGEGRGIAML
   601  NLLRTLSQSI APSMADMWEL EIALLVRYLE EHTEFTWDQK AWEDKLIQFL RNSLKKTRGS
   661  SWSLRLSKEL NNQIASFDSP SLEKGFLYRA LGFTLATGLE ASKVEVLLLE LLYKTDYSND
   721  FDSEGVIMCF GLCARGQVKT VLNVLHDFEE RIQESEQSWQ ISAWRKDHPW RRETVKSALM
   781  VMYSCVASYC HPQLLLNLVD SPITAKIIHH YVSSCQDICL KMAFMKSVVQ VTKAINNIKD
   841  LEDFHFAQKT TLTSIIVAVI KAEPTDNLVS PVRALAMEAL SHLSKLKPFY STEENSELMD
   901  ISIHSVISLQ LPGEDNESIK TLYANALSSL EQLMESLLQR QLDPKGLQEM VQLLEKWILS
   961  EKEWEREKAV SLHLYLMWIY VHSTAVCIHL KLGQFGTMVG LIAPCTCDAH QRTRMASMNV
  1021  LSSLLDLHAS QTCSLWGPSK QKELEKCKGD LQSTDVEKIF CASSRIAKVV CMEFSCDEVV
  1081  SLIQKLCENT GAMNLQHDKA SVTWIAFFLQ MRAKELEDKV AEILSAILVH LPVVDHPEVR
  1141  RLLIDGILLL AHHHQETILT SLLRQPLPME SHLAEVWLAV SENVPFARTM LHSLMGRLQS
  1201  RLSPRISATS KADIWRLAAV DPLMTLCTIH LLIQKLDEND KLPDFLPDLI YTLLLQLGSS
  1261  HRPEAAPPVL KMWKLVHTTP LPEEMNLQRV TIKSMQLLFK RVKSQHLAHT LDEQAVWDLL
  1321  QDGGTFLEGV SLLARLCMQH VEGHRQRLAE LVLRGMDSEV LSCRISSTAV CFMSGPVLYQ
  1381  EKLLKPAALL LEKGADQEED EALRVLSLRA LGNMALGAPK KVKQYRKVLL EKCLGPLREP
  1441  VSNSVTAEGM EALTKILAEL REGDVGSSFD AMSEQCRIFF DNESELLRLK AFILFGKLAR
  1501  VVGMSKKHFF KGEVKKAWIP LMLHSQDPCS NAAQACMATM FQCVHFWGWK SLEHPSGPSD
  1561  TATDDKMTVF QTTMCSILTR KKPAVLYRFL LETMAYVKNN LSRIRIAACN LAGIIMKQMS
  1621  THYLKKLDFP ALRNSLQELQ LDPDPGVRRA ALETLTVLDS CSQHGFLASP QGMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MROH2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
1.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.6 nTPM
  • thyroid gland: 1.5 nTPM
  • liver: 0.5 nTPM
  • stomach: 0.4 nTPM
  • kidney: 0.2 nTPM
  • epididymis: 0.1 nTPM

Single-cell type

  • urothelial cells: 13 nCPM
  • proximal tubule cells: 11 nCPM
  • late spermatids: 8.3 nCPM
  • early spermatids: 5 nCPM
  • esophageal basal cells: 5 nCPM
  • undifferentiated spermatogonia: 3.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.4 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
2.1

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MROH2A as an antibody target. Whether an autoantibody or antibody against MROH2A could matter depends on whether native MROH2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MROH2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MROH2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MROH2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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