Seroatlas · Human Serome Atlas

MROH1

Maestro heat-like repeat-containing protein family member 1

Also known as: HEATR7A, KIAA1833, MROH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NDA8
Gene
MROH1
Ensembl
ENSG00000179832
Chromosome
8
Canonical length
1641 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1641 residues, UniProt reviewed canonical sequence.

>Q8NDA8|MROH1
     1  MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP
    61  YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ
   121  FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT
   181  VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR
   241  LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR
   301  TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT
   361  SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH
   421  GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM
   481  SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT
   541  GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ
   601  EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS
   661  SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG
   721  ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKVLGIK
   781  VETKDPALKL CLVQSVCMVS RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI
   841  RKKAMLTCTY LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL
   901  EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF LEHLRVSALV
   961  PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG YEGFSRDYRD DVAERLLSLK
  1021  DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ LISLLLTMFE ALGDPEKNCS RAATVMINCL
  1081  LQERGGVLQE KVPEIVSVLR SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP
  1141  LDSHTCMLWR ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT
  1201  CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG ASPALATRNL
  1261  EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG HEEGATRLAR AMAEHAGPRL
  1321  PLVLKTLACT HSSAYENQRV TTTAFLAELL NSNVANDLML LDSLLESLAA RQKDTCASVR
  1381  RLVLRGLANL ASGCPDKVRT HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES
  1441  WDLRSGLLHV AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL
  1501  LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL NTTCKHLMHH
  1561  FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP RQQPQVDLDQ LIAALQILLK
  1621  DPAPEVRTRA AEALGRLVKL A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MROH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 46 nTPM
  • pancreas: 17 nTPM
  • cerebellum: 17 nTPM
  • bone marrow: 16 nTPM
  • spleen: 15 nTPM
  • cerebral cortex: 15 nTPM

Single-cell type

  • gonadotrophs: 208 nCPM
  • retinal ganglion cells: 189 nCPM
  • syncytiotrophoblasts: 171 nCPM
  • somatotrophs: 150 nCPM
  • podocytes: 145 nCPM
  • choroid plexus epithelial cells: 135 nCPM

Immune cell

  • intermediate monocyte: 7.7 nTPM
  • non-classical monocyte: 6.9 nTPM
  • classical monocyte: 5.7 nTPM
  • basophil: 4.9 nTPM
  • T-reg: 4.6 nTPM
  • myeloid DC: 4.2 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • pons: 39 nTPM
  • choroid plexus: 34 nTPM
  • hippocampal formation: 33 nTPM
  • medulla oblongata: 32 nTPM
  • amygdala: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.2
gnomAD missense Z
0.6
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • lysosome fission

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MROH1 as an antibody target. Whether an autoantibody or antibody against MROH1 could matter depends on whether native MROH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MROH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MROH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MROH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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