Seroatlas · Human Serome Atlas

MRO

Protein maestro

Also known as: B29, C18orf3, FLJ30140, MSTRO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYG7
Gene: MRO
Ensembl: ENSG00000134042
Chromosome: 18
Canonical length: 248 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q9BYG7|MRO
     1  MDQRQRRILG QPLSIPTSQP KQKRTSMISF FSKVSWKLRF QKREPLKNVF FILAERARDP
    61  SAKKRHMAMR NLGTMAYEAP DKVRKYKKIV LDLLVYGLYD PVNLEVIHES MKTLTVVLGK
   121  IQGKGLGSFF IDITLQTRTL LDDENDSLRY SAFVLFGQLA AFAGRKWKKF FTSQVKQTRD
   181  SLLIHLQDRN PQVAKACKTT FQACSPYLKL KEEYSFQSEE DQRNTKLYQQ LSHYHPEILQ
   241  FFYANKIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

midbrain: 36 nTPM
basal ganglia: 36 nTPM
amygdala: 33 nTPM
cerebral cortex: 30 nTPM
testis: 27 nTPM
hypothalamus: 26 nTPM

Single-cell type

sertoli cells: 104 nCPM
astrocytes: 47 nCPM
kupffer cells: 35 nCPM
proximal tubule cells: 30 nCPM
enterocytes: 21 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

hypothalamus: 71 nTPM
basal ganglia: 65 nTPM
thalamus: 62 nTPM
midbrain: 58 nTPM
amygdala: 53 nTPM
medulla oblongata: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleolus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRO as an antibody target. Whether an autoantibody or antibody against MRO could matter depends on whether native MRO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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