Seroatlas · Human Serome Atlas

MRM2

rRNA methyltransferase 2, mitochondrial

Also known as: FJH1, FTSJ2, MRM2_HUMAN, RRMJ2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UI43
Gene
MRM2
Ensembl
ENSG00000122687
Chromosome
7
Canonical length
246 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q9UI43|MRM2
     1  MAGYLKLVCV SFQRQGFHTV GSRCKNRTGA EHLWLTRHLR DPFVKAAKVE SYRCRSAFKL
    61  LEVNERHQIL RPGLRVLDCG AAPGAWSQVA VQKVNAAGTD PSSPVGFVLG VDLLHIFPLE
   121  GATFLCPADV TDPRTSQRIL EVLPGRRADV ILSDMAPNAT GFRDLDHDRL ISLCLTLLSV
   181  TPDILQPGGT FLCKTWAGSQ SRRLQRRLTE EFQNVRIIKP EASRKESSEV YFLATQYHGR
   241  KGTVKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 20 nTPM
  • tonsil: 17 nTPM
  • lymph node: 17 nTPM
  • liver: 16 nTPM
  • choroid plexus: 16 nTPM
  • spleen: 15 nTPM

Single-cell type

  • microglia: 12 nCPM
  • papillary tip epithelial cells: 9.7 nCPM
  • other brain neurons: 9 nCPM
  • brain excitatory neurons: 8.2 nCPM
  • loop of henle epithelial cells: 7.8 nCPM
  • renal collecting duct principal cells: 7.5 nCPM

Immune cell

  • myeloid DC: 72 nTPM
  • intermediate monocyte: 57 nTPM
  • memory B-cell: 52 nTPM
  • classical monocyte: 49 nTPM
  • non-classical monocyte: 49 nTPM
  • naive B-cell: 49 nTPM

Brain region

  • choroid plexus: 7.2 nTPM
  • spinal cord: 6.8 nTPM
  • white matter: 6.8 nTPM
  • medulla oblongata: 6.5 nTPM
  • cerebral cortex: 6.1 nTPM
  • cerebellum: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRM2.

Disease | AllUniProt

Conditions MRM2 is implicated in, by any mechanism.

  • Mitochondrial DNA depletion syndrome 17 (MTDPS17) MIM:618567

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 20 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mitochondrial DNA depletion syndrome 17

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRM2 as an antibody target. Whether an autoantibody or antibody against MRM2 could matter depends on whether native MRM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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