MRLN
Myoregulin
Also known as: Linc-RAM, LINC00948, M1, MLN, MLN_HUMAN, MUSER1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DMT0
- Gene
- MRLN
- Ensembl
- ENSG00000227877
- Chromosome
- 10
- Canonical length
- 46 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]
Canonical amino-acid sequenceUniProt
46 residues, UniProt reviewed canonical sequence.
>P0DMT0|MRLN
1 MTGKNWILIS TTTPKSLEDE IVGRLLKILF VIFVDLISII YVVITSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MRLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 177 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 177 nTPM
- tongue: 137 nTPM
- cerebellum: 42 nTPM
- retina: 28 nTPM
- choroid plexus: 11 nTPM
- pituitary gland: 7.7 nTPM
Single-cell type
- endometrial ciliated cells: 116 nCPM
- fallopian tube ciliated cells: 102 nCPM
- epididymal efferent duct ciliated cells: 94 nCPM
- thymic myoid cells: 84 nCPM
- rod photoreceptor cells: 70 nCPM
- myonuclei: 46 nCPM
Immune cell
- basophil: 1.8 nTPM
- neutrophil: 1.2 nTPM
- gdT-cell: 0.6 nTPM
- naive B-cell: 0.6 nTPM
- memory B-cell: 0.5 nTPM
- naive CD8 T-cell: 0.5 nTPM
Brain region
- cerebellum: 11 nTPM
- pons: 3.2 nTPM
- white matter: 2.6 nTPM
- cerebral cortex: 2.5 nTPM
- hippocampal formation: 2.3 nTPM
- medulla oblongata: 2.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Myoregulin
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MRLN as an antibody target. Whether an autoantibody or antibody against MRLN could matter depends on whether native MRLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MRLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MRLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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