Seroatlas · Human Serome Atlas

MRI1

Methylthioribose-1-phosphate isomerase

Also known as: MGC3207, MRDI, mtnA, MTNA_HUMAN, Ypr118w

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV20
Gene
MRI1
Ensembl
ENSG00000037757
Chromosome
19
Canonical length
369 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q9BV20|MRI1
     1  MTLEAIRYSR GSLQILDQLL LPKQSRYEAV GSVHQAWEAI RAMKVRGAPA IALVGCLSLA
    61  VELQAGAGGP GLAALVAFVR DKLSFLVTAR PTAVNMARAA RDLADVAARE AEREGATEEA
   121  VRERVICCTE DMLEKDLRDN RSIGDLGARH LLERVAPSGG KVTVLTHCNT GALATAGYGT
   181  ALGVIRSLHS LGRLEHAFCT ETRPYNQGAR LTAFELVYEQ IPATLITDSM VAAAMAHRGV
   241  SAVVVGADRV VANGDTANKV GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIIIEER
   301  PGQELTDVNG VRIAAPGIGV WNPAFDVTPH DLITGGIITE LGVFAPEELR TALTTTISSR
   361  DGTLDGPQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • skin: 21 nTPM
  • ovary: 20 nTPM
  • cervix: 20 nTPM
  • cerebellum: 19 nTPM
  • liver: 19 nTPM
  • spleen: 19 nTPM

Single-cell type

  • bergmann glia: 42 nCPM
  • other brain neurons: 42 nCPM
  • brain excitatory neurons: 40 nCPM
  • brain inhibitory neurons: 39 nCPM
  • adipocytes: 38 nCPM
  • fibro-adipogenic progenitors: 36 nCPM

Immune cell

  • basophil: 3.3 nTPM
  • plasmacytoid DC: 2.7 nTPM
  • memory CD8 T-cell: 2.1 nTPM
  • classical monocyte: 1.8 nTPM
  • MAIT T-cell: 1.8 nTPM
  • NK-cell: 1.8 nTPM

Brain region

  • white matter: 23 nTPM
  • cerebellum: 20 nTPM
  • medulla oblongata: 19 nTPM
  • pons: 19 nTPM
  • cerebral cortex: 19 nTPM
  • thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRI1 as an antibody target. Whether an autoantibody or antibody against MRI1 could matter depends on whether native MRI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRI1 is annotated at the cell surface, where native MRI1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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