MRGPRX4
Mas-related G-protein coupled receptor member X4
Also known as: MRGX4, MRGX4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96LA9
- Gene
- MRGPRX4
- Ensembl
- ENSG00000179817
- Chromosome
- 11
- Canonical length
- 322 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
322 residues, UniProt reviewed canonical sequence.
>Q96LA9|MRGPRX4
1 MDPTVPVFGT KLTPINGREE TPCYNQTLSF TVLTCIISLV GLTGNAVVLW LLGYRMRRNA
61 VSIYILNLAA ADFLFLSFQI IRLPLRLINI SHLIRKILVS VMTFPYFTGL SMLSAISTER
121 CLSVLWPIWY RCRRPTHLSA VVCVLLWGLS LLFSMLEWRF CDFLFSGADS SWCETSDFIP
181 VAWLIFLCVV LCVSSLVLLV RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGILGALIY
241 RMHLNLEVLY CHVYLVCMSL SSLNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDKPE
301 VDKGEGQLPE ESLELSGSRL GPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MRGPRX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- epididymal basal cells: 0.5 nCPM
- early primary spermatocytes: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- pons: 0.3 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.62
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- G protein-coupled receptor signaling pathway
- phospholipase C-activating G protein-coupled receptor signaling pathway
- sensory perception of itch
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MRGPRX4 as an antibody target. Whether an autoantibody or antibody against MRGPRX4 could matter depends on whether native MRGPRX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MRGPRX4 is annotated at the cell surface, where native MRGPRX4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MRGPRX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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