Seroatlas · Human Serome Atlas

MRGPRX3

Mas-related G-protein coupled receptor member X3

Also known as: MRGX3, MRGX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LB0
Gene: MRGPRX3
Ensembl: ENSG00000179826
Chromosome: 11
Canonical length: 322 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q96LB0|MRGPRX3
     1  MDSTIPVLGT ELTPINGREE TPCYKQTLSF TGLTCIVSLV ALTGNAVVLW LLGCRMRRNA
    61  VSIYILNLVA ADFLFLSGHI ICSPLRLINI RHPISKILSP VMTFPYFIGL SMLSAISTER
   121  CLSILWPIWY HCRRPRYLSS VMCVLLWALS LLRSILEWMF CDFLFSGANS VWCETSDFIT
   181  IAWLVFLCVV LCGSSLVLLV RILCGSRKMP LTRLYVTILL TVLVFLLCGL PFGIQWALFS
   241  RIHLDWKVLF CHVHLVSIFL SALNSSANPI IYFFVGSFRQ RQNRQNLKLV LQRALQDTPE
   301  VDEGGGWLPQ ETLELSGSRL EQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRGPRX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 2.5 nTPM
esophagus: 0.9 nTPM
breast: 0.5 nTPM
appendix: 0.3 nTPM
testis: 0.3 nTPM
spleen: 0.2 nTPM

Single-cell type

salivary myoepithelial cells: 5.8 nCPM
early primary spermatocytes: 3.6 nCPM
esophageal basal cells: 3.5 nCPM
breast myoepithelial cells: 2.6 nCPM
esophageal suprabasal cells: 2.6 nCPM
smooth muscle cells: 2.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 3.1 nTPM
white matter: 3 nTPM
cerebellum: 2.9 nTPM
hippocampal formation: 2.8 nTPM
midbrain: 2.8 nTPM
amygdala: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.85
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRGPRX3 as an antibody target. Whether an autoantibody or antibody against MRGPRX3 could matter depends on whether native MRGPRX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRGPRX3 is annotated at the cell surface, where native MRGPRX3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRGPRX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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