Seroatlas · Human Serome Atlas

MRGPRX2

Mas-related G-protein coupled receptor member X2

Also known as: MRGX2, MRGX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LB1
Gene: MRGPRX2
Ensembl: ENSG00000183695
Chromosome: 11
Canonical length: 330 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q96LB1|MRGPRX2
     1  MDPTTPAWGT ESTTVNGNDQ ALLLLCGKET LIPVFLILFI ALVGLVGNGF VLWLLGFRMR
    61  RNAFSVYVLS LAGADFLFLC FQIINCLVYL SNFFCSISIN FPSFFTTVMT CAYLAGLSML
   121  STVSTERCLS VLWPIWYRCR RPRHLSAVVC VLLWALSLLL SILEGKFCGF LFSDGDSGWC
   181  QTFDFITAAW LIFLFMVLCG SSLALLVRIL CGSRGLPLTR LYLTILLTVL VFLLCGLPFG
   241  IQWFLILWIW KDSDVLFCHI HPVSVVLSSL NSSANPIIYF FVGSFRKQWR LQQPILKLAL
   301  QRALQDIAEV DHSEGCFRQG TPEMSRSSLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRGPRX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

skin: 0.9 nTPM
breast: 0.8 nTPM
adipose tissue: 0.6 nTPM
urinary bladder: 0.5 nTPM
cervix: 0.3 nTPM
epididymis: 0.2 nTPM

Single-cell type

mast cells: 14 nCPM
melanocytes: 2 nCPM
early spermatids: 1.4 nCPM
hematopoietic stem cells: 1 nCPM
late spermatids: 0.4 nCPM
pericytes: 0.3 nCPM

Immune cell

gdT-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.37
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled opioid receptor activity
G protein-coupled receptor activity
neuropeptide binding
mast cell secretagogue receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRGPRX2 as an antibody target. Whether an autoantibody or antibody against MRGPRX2 could matter depends on whether native MRGPRX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRGPRX2 is annotated at the cell surface, where native MRGPRX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRGPRX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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