Seroatlas · Human Serome Atlas

MRGPRG

Mas-related G-protein coupled receptor member G

Also known as: GPR169, mrgG, MRGRG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SM5
Gene: MRGPRG
Ensembl: ENSG00000182170
Chromosome: 11
Canonical length: 289 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q86SM5|MRGPRG
     1  MFGLFGLWRT FDSVVFYLTL IVGLGGPVGN GLVLWNLGFR IKKGPFSIYL LHLAAADFLF
    61  LSCRVGFSVA QAALGAQDTL YFVLTFLWFA VGLWLLAAFS VERCLSDLFP ACYQGCRPRH
   121  ASAVLCALVW TPTLPAVPLP ANACGLLRNS ACPLVCPRYH VASVTWFLVL ARVAWTAGVV
   181  LFVWVTCCST RPRPRLYGIV LGALLLLFFC GLPSVFYWSL QPLLNFLLPV FSPLATLLAC
   241  VNSSSKPLIY SGLGRQPGKR EPLRSVLRRA LGEGAELGAR GQSLPMGLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRGPRG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.3 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.01
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Mas-related G protein-coupled receptor family
Mas-related G protein-coupled receptor G

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRGPRG as an antibody target. Whether an autoantibody or antibody against MRGPRG could matter depends on whether native MRGPRG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRGPRG is annotated at the cell surface, where native MRGPRG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRGPRG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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