MRGPRF
Mas-related G-protein coupled receptor member F
Also known as: GPR140, GPR168, MGC21621, mrgF, MRGRF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96AM1
- Gene
- MRGPRF
- Ensembl
- ENSG00000172935
- Chromosome
- 11
- Canonical length
- 343 aa
- Protein class
- G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Nuclear membrane,Plasma membrane,Primary cilium transition zone
OverviewNCBI Gene
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in nuclear membrane; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
343 residues, UniProt reviewed canonical sequence.
>Q96AM1|MRGPRF
1 MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI FLLLCLCGLV
61 GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS ILNTGGFLGT FADYIRSVCR
121 VLGLCMFLTG VSLLPAVSAE RCASVIFPAW YWRRRPKRLS AVVCALLWVL SLLVTCLHNY
181 FCVFLGRGAP GAACRHMDIF LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV
241 ILAMVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
301 RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MRGPRF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 170 nTPM
Expression across tissuesHPA
Tissue
- endometrium: 170 nTPM
- colon: 162 nTPM
- fallopian tube: 133 nTPM
- cervix: 126 nTPM
- blood vessel: 97 nTPM
- urinary bladder: 79 nTPM
Single-cell type
- smooth muscle cells: 158 nCPM
- decidual stromal cells: 136 nCPM
- vascular smooth muscle cells: 128 nCPM
- peritubular myoid cells: 102 nCPM
- pericytes: 81 nCPM
- hepatic stellate cells: 65 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 22 nTPM
- choroid plexus: 8.6 nTPM
- medulla oblongata: 6.9 nTPM
- cerebral cortex: 4.4 nTPM
- pons: 4.1 nTPM
- hypothalamus: 3.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.97
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.65
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- G protein-coupled receptor, rhodopsin-like
- GPCR, rhodopsin-like, 7TM
- Mas-related G protein-coupled receptor family
- 7 transmembrane receptor (rhodopsin family)
- Mas-related G protein-coupled receptor F
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MRGPRF as an antibody target. Whether an autoantibody or antibody against MRGPRF could matter depends on whether native MRGPRF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MRGPRF is annotated at the cell surface, where native MRGPRF is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MRGPRF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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