Seroatlas · Human Serome Atlas

MRGPRE

Mas-related G-protein coupled receptor member E

Also known as: GPR167, mrgE, MRGRE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SM8
Gene: MRGPRE
Ensembl: ENSG00000184350
Chromosome: 11
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q86SM8|MRGPRE
     1  MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS SNVYRNPFAI
    61  YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA TLRFFCYIVG LSLLAAVSVE
   121  QCLAALFPAW YSCRRPRHLT TCVCALTWAL CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV
   181  AAVLLALLCC TMCGASLMLL LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR
   241  NLLWYIPHYF YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
   301  ETSRRGLVDI AA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRGPRE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

cervix: 1.4 nTPM
hypothalamus: 1.4 nTPM
midbrain: 1.1 nTPM
spinal cord: 0.9 nTPM
endometrium: 0.8 nTPM
vagina: 0.8 nTPM

Single-cell type

pancreatic islet cells: 2.2 nCPM
salivary duct cells: 1 nCPM
breast myoepithelial cells: 0.9 nCPM
brain excitatory neurons: 0.8 nCPM
fibroblasts: 0.8 nCPM
other brain neurons: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 58 nTPM
medulla oblongata: 31 nTPM
hypothalamus: 14 nTPM
cerebellum: 8.5 nTPM
spinal cord: 7.1 nTPM
midbrain: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.24
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Mas-related G protein-coupled receptor family
7 transmembrane receptor (rhodopsin family)
Mas-related G protein-coupled receptor E

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRGPRE as an antibody target. Whether an autoantibody or antibody against MRGPRE could matter depends on whether native MRGPRE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRGPRE is annotated at the cell surface, where native MRGPRE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRGPRE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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