Seroatlas · Human Serome Atlas

MRGPRD

Mas-related G-protein coupled receptor member D

Also known as: mrgD, MRGRD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDS7
Gene: MRGPRD
Ensembl: ENSG00000172938
Chromosome: 11
Canonical length: 321 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q8TDS7|MRGPRD
     1  MNQTLNSSGT VESALNYSRG STVHTAYLVL SSLAMFTCLC GMAGNSMVIW LLGFRMHRNP
    61  FCIYILNLAA ADLLFLFSMA STLSLETQPL VNTTDKVHEL MKRLMYFAYT VGLSLLTAIS
   121  TQRCLSVLFP IWFKCHRPRH LSAWVCGLLW TLCLLMNGLT SSFCSKFLKF NEDRCFRVDM
   181  VQAALIMGVL TPVMTLSSLT LFVWVRRSSQ QWRRQPTRLF VVVLASVLVF LICSLPLSIY
   241  WFVLYWLSLP PEMQVLCFSL SRLSSSVSSS ANPVIYFLVG SRRSHRLPTR SLGTVLQQAL
   301  REEPELEGGE TPTVGTNEMG A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRGPRD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

colon: 0.6 nTPM
cerebellum: 0.5 nTPM
blood vessel: 0.4 nTPM
endometrium: 0.4 nTPM
cervix: 0.2 nTPM
fallopian tube: 0.2 nTPM

Single-cell type

peritubular myoid cells: 0.2 nCPM
smooth muscle cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.6 nTPM
basal ganglia: 1 nTPM
cerebral cortex: 0.9 nTPM
amygdala: 0.4 nTPM
pons: 0.4 nTPM
white matter: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.17
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Mas-related G protein-coupled receptor family
7 transmembrane receptor (rhodopsin family)
Mas-related G protein-coupled receptor D

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRGPRD as an antibody target. Whether an autoantibody or antibody against MRGPRD could matter depends on whether native MRGPRD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRGPRD is annotated at the cell surface, where native MRGPRD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MRGPRD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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