Seroatlas · Human Serome Atlas

MRFAP1L2

MORF4 family associated protein 1 like 2

Also known as: ENSG00000170846, MR1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B2RBV5
Gene
MRFAP1L2
Ensembl
ENSG00000170846
Chromosome
4
Canonical length
119 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in regulation of cell cycle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>B2RBV5|MRFAP1L2
     1  MRPVDADEAR EPREEPGSPL SPAPRAGREN LASLERERAR AHWRARRKLL EIQSLLDAIK
    61  SEVEAEERGA RAPAPRPRAE AEERVARLCA EAERKAAEAA RMGRRIVELH QRIAGCECC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRFAP1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
7.9 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 7.9 nTPM
  • skin: 7.5 nTPM
  • cerebral cortex: 7.1 nTPM
  • pituitary gland: 7.1 nTPM
  • basal ganglia: 6 nTPM
  • spleen: 5.4 nTPM

Single-cell type

  • cardiomyocytes: 51 nCPM
  • prostatic club cells: 40 nCPM
  • oocytes: 28 nCPM
  • epididymal principal cells: 27 nCPM
  • esophageal apical cells: 27 nCPM
  • megakaryocytes: 25 nCPM

Immune cell

  • memory CD4 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM

Brain region

  • hypothalamus: 10 nTPM
  • cerebral cortex: 6.7 nTPM
  • basal ganglia: 6.5 nTPM
  • hippocampal formation: 6.2 nTPM
  • amygdala: 5.7 nTPM
  • white matter: 4.9 nTPM

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRFAP1L2 as an antibody target. Whether an autoantibody or antibody against MRFAP1L2 could matter depends on whether native MRFAP1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRFAP1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRFAP1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRFAP1L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...