Seroatlas · Human Serome Atlas

MPZL3

Myelin protein zero-like protein 3

Also known as: MPZL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWV2
Gene: MPZL3
Ensembl: ENSG00000160588
Chromosome: 11
Canonical length: 235 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in cell adhesion. Predicted to act upstream of or within extracellular matrix organization and hair cycle. Predicted to be located in membrane. Predicted to be active in plasma membrane. Implicated in lung cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q6UWV2|MPZL3
     1  MQQRGAAGSR GCALFPLLGV LFFQGVYIVF SLEIRADAHV RGYVGEKIKL KCTFKSTSDV
    61  TDKLTIDWTY RPPSSSHTVS IFHYQSFQYP TTAGTFRDRI SWVGNVYKGD ASISISNPTI
   121  KDNGTFSCAV KNPPDVHHNI PMTELTVTER GFGTMLSSVA LLSILVFVPS AVVVALLLVR
   181  MGRKAAGLKK RSRSGYKKSS IEVSDDTDQE EEEACMARLC VRCAECLDSD YEETY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPZL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

esophagus: 32 nTPM
skin: 29 nTPM
vagina: 17 nTPM
tonsil: 12 nTPM
cervix: 11 nTPM
salivary gland: 11 nTPM

Single-cell type

esophageal apical cells: 694 nCPM
t-cells: 231 nCPM
enterocytes: 215 nCPM
ocular epithelial cells: 206 nCPM
innate lymphoid cells: 202 nCPM
neutrophils: 146 nCPM

Immune cell

eosinophil: 99 nTPM
neutrophil: 88 nTPM
basophil: 44 nTPM
MAIT T-cell: 29 nTPM
memory CD4 T-cell: 11 nTPM
memory CD8 T-cell: 9.6 nTPM

Brain region

cerebellum: 6.2 nTPM
choroid plexus: 4.1 nTPM
pons: 2.5 nTPM
basal ganglia: 2.4 nTPM
hypothalamus: 2.2 nTPM
thalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.31
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPZL3 as an antibody target. Whether an autoantibody or antibody against MPZL3 could matter depends on whether native MPZL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPZL3 is annotated at the cell surface, where native MPZL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MPZL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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