Seroatlas · Human Serome Atlas

MPV17L2

Mpv17-like protein 2

Also known as: FKSG24, M17L2_HUMAN, MGC12972

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q567V2
Gene: MPV17L2
Ensembl: ENSG00000254858
Chromosome: 19
Canonical length: 206 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables mitochondrial large ribosomal subunit binding activity. Involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q567V2|MPV17L2
     1  MARGGWRRLR RLLSAGQLLF QGRALLVTNT LGCGALMAAG DGVRQSWEIR ARPGQVFDPR
    61  RSASMFAVGC SMGPFLHYWY LSLDRLFPAS GLRGFPNVLK KVLVDQLVAS PLLGVWYFLG
   121  LGCLEGQTVG ESCQELREKF WEFYKADWCV WPAAQFVNFL FVPPQFRVTY INGLTLGWDT
   181  YLSYLKYRSP VPLTPPGCVA LDTRAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPV17L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 18 nTPM
liver: 18 nTPM
heart muscle: 16 nTPM
tongue: 15 nTPM
skeletal muscle: 13 nTPM
colon: 13 nTPM

Single-cell type

epididymal principal cells: 69 nCPM
breast lactating cells: 44 nCPM
extravillous trophoblasts: 35 nCPM
cytotrophoblasts: 28 nCPM
syncytiotrophoblasts: 27 nCPM
migrating cytotrophoblasts: 26 nCPM

Immune cell

intermediate monocyte: 27 nTPM
memory B-cell: 26 nTPM
myeloid DC: 25 nTPM
plasmacytoid DC: 24 nTPM
classical monocyte: 19 nTPM
MAIT T-cell: 19 nTPM

Brain region

white matter: 12 nTPM
midbrain: 11 nTPM
pons: 11 nTPM
thalamus: 11 nTPM
medulla oblongata: 11 nTPM
hypothalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mitochondrial large ribosomal subunit binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPV17L2 as an antibody target. Whether an autoantibody or antibody against MPV17L2 could matter depends on whether native MPV17L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPV17L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPV17L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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