MPV17L
Mpv17-like protein
Also known as: FLJ39599, MLPH1, MLPH2, MP17L_HUMAN, MPV17L1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q2QL34
- Gene
- MPV17L
- Ensembl
- ENSG00000156968
- Chromosome
- 16
- Canonical length
- 196 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Involved in negative regulation of hydrogen peroxide biosynthetic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and reactive oxygen species metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
196 residues, UniProt reviewed canonical sequence.
>Q2QL34|MPV17L
1 MAGWWPALSR AARRHPWPTN VLLYGSLVSA GDALQQRLQG REANWRQTRR VATLVVTFHA
61 NFNYVWLRLL ERALPGRAPH ALLAKLLCDQ VVGAPIAVSA FYVGMSILQG KDDIFLDLKQ
121 KFWNTYLSGL MYWPFVQLTN FSLVPVQWRT AYAGVCGFLW ATFICFSQQS GDGTFKSAFT
181 ILYTKGTSAT EGYPKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MPV17L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 12 nTPM
- liver: 7.8 nTPM
- skeletal muscle: 6.5 nTPM
- breast: 6 nTPM
- salivary gland: 5.6 nTPM
- bone marrow: 4 nTPM
Single-cell type
- late primary spermatocytes: 2.9 nCPM
- thymic myoid cells: 2.7 nCPM
- conjunctival goblet cells: 1.9 nCPM
- innate lymphoid cells: 1.7 nCPM
- breast lactating cells: 1.5 nCPM
- endometrial secretory cells: 1.3 nCPM
Immune cell
- neutrophil: 1.6 nTPM
- basophil: 1.4 nTPM
- classical monocyte: 1.2 nTPM
- naive B-cell: 1.1 nTPM
- NK-cell: 1 nTPM
- intermediate monocyte: 0.9 nTPM
Brain region
- cerebral cortex: 41 nTPM
- cerebellum: 32 nTPM
- midbrain: 30 nTPM
- thalamus: 29 nTPM
- amygdala: 28 nTPM
- pons: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.77
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.45
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of hydrogen peroxide biosynthetic process
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- reactive oxygen species metabolic process
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MPV17L as an antibody target. Whether an autoantibody or antibody against MPV17L could matter depends on whether native MPV17L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MPV17L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MPV17L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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