Seroatlas · Human Serome Atlas

MPLKIP

M-phase-specific PLK1-interacting protein

Also known as: C7orf11, MPLKI_HUMAN, ORF20, TTDN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAP9
Gene: MPLKIP
Ensembl: ENSG00000168303
Chromosome: 7
Canonical length: 179 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q8TAP9|MPLKIP
     1  MQRQNFRPPT PPYPGPGGGG WGSGSSFRGT PGGGGPRPPS PRDGYGSPHH TPPYGPRSRP
    61  YGSSHSPRHG GSFPGGRFGS PSPGGYPGSY SRSPAGSQQQ FGYSPGQQQT HPQGSPRTST
   121  PFGSGRVREK RMSNELENYF KPSMLEDPWA GLEPVSVVDI SQQYSNTQTF TGKKGRYFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPLKIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

liver: 7.5 nTPM
kidney: 4 nTPM
adrenal gland: 3.6 nTPM
cerebellum: 3.1 nTPM
thymus: 3.1 nTPM
esophagus: 2.9 nTPM

Single-cell type

early spermatids: 169 nCPM
hepatocytes: 163 nCPM
esophageal basal cells: 145 nCPM
esophageal suprabasal cells: 145 nCPM
esophageal apical cells: 132 nCPM
migrating cytotrophoblasts: 131 nCPM

Immune cell

basophil: 20 nTPM
memory B-cell: 17 nTPM
eosinophil: 17 nTPM
naive B-cell: 15 nTPM
T-reg: 14 nTPM
total PBMC: 13 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 11 nTPM
cerebral cortex: 9.4 nTPM
choroid plexus: 9.2 nTPM
basal ganglia: 8.7 nTPM
hippocampal formation: 8.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MPLKIP.

Disease | AllUniProt

Conditions MPLKIP is implicated in, by any mechanism.

Trichothiodystrophy 4, non-photosensitive (TTD4) MIM:234050

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 174 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Trichothiodystrophy 4, nonphotosensitive
Trichothiodystrophy 1, photosensitive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell division

Cellular components

Protein domainsUniProt · Pfam · InterPro

M-phase-specific PLK1-interacting protein-like, vertebrate
TTDN1/Protein SICKLE
M-phase-specific PLK1-interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPLKIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PLK1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPLKIP as an antibody target. Whether an autoantibody or antibody against MPLKIP could matter depends on whether native MPLKIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPLKIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPLKIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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