Seroatlas · Human Serome Atlas

MPG

DNA-3-methyladenine glycosylase

Also known as: 3MG_HUMAN, MDG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P29372
Gene: MPG
Ensembl: ENSG00000103152
Chromosome: 16
Canonical length: 298 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables DNA binding activity. Predicted to be involved in base-excision repair. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>P29372|MPG
     1  MVTPALQMKK PKQFCRRMGQ KKQRPARAGQ PHSSSDAAQA PAEQPHSSSD AAQAPCPRER
    61  CLGPPTTPGP YRSIYFSSPK GHLTRLGLEF FDQPAVPLAR AFLGQVLVRR LPNGTELRGR
   121  IVETEAYLGP EDEAAHSRGG RQTPRNRGMF MKPGTLYVYI IYGMYFCMNI SSQGDGACVL
   181  LRALEPLEGL ETMRQLRSTL RKGTASRVLK DRELCSGPSK LCQALAINKS FDQRDLAQDE
   241  AVWLERGPLE PSEPAVVAAA RVGVGHAGEW ARKPLRFYVR GSPWVSVVDR VAEQDTQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 100 nTPM
skeletal muscle: 76 nTPM
liver: 73 nTPM
adrenal gland: 70 nTPM
pancreas: 65 nTPM
heart muscle: 64 nTPM

Single-cell type

decidual stromal cells: 179 nCPM
esophageal basal cells: 154 nCPM
esophageal suprabasal cells: 141 nCPM
megakaryocytes: 130 nCPM
extravillous trophoblasts: 123 nCPM
plasma cells: 115 nCPM

Immune cell

NK-cell: 130 nTPM
plasmacytoid DC: 111 nTPM
memory B-cell: 93 nTPM
T-reg: 91 nTPM
naive B-cell: 86 nTPM
eosinophil: 81 nTPM

Brain region

thalamus: 31 nTPM
cerebral cortex: 29 nTPM
hypothalamus: 29 nTPM
spinal cord: 28 nTPM
white matter: 28 nTPM
amygdala: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: -0.49
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

damaged DNA binding
DNA binding
DNA N-glycosylase activity
alkylbase DNA N-glycosylase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Formyl transferase-like, C-terminal domain superfamily
Methylpurine-DNA glycosylase
Methylpurine-DNA glycosylase superfamily
Methylpurine-DNA glycosylase (MPG)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRNP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPG as an antibody target. Whether an autoantibody or antibody against MPG could matter depends on whether native MPG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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