Seroatlas · Human Serome Atlas

MPEG1

Macrophage-expressed gene 1 protein

Also known as: MPEG1_HUMAN, MPG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2M385
Gene
MPEG1
Ensembl
ENSG00000197629
Chromosome
11
Canonical length
716 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters
Secretome location
Secreted to blood
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables wide pore channel activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in cytoplasmic vesicle. Is active in phagolysosome membrane. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q2M385|MPEG1
     1  MNNFRATILF WAAAAWAKSG KPSGEMDEVG VQKCKNALKL PVLEVLPGGG WDNLRNVDMG
    61  RVMELTYSNC RTTEDGQYII PDEIFTIPQK QSNLEMNSEI LESWANYQSS TSYSINTELS
   121  LFSKVNGKFS TEFQRMKTLQ VKDQAITTRV QVRNLVYTVK INPTLELSSG FRKELLDISD
   181  RLENNQTRMA TYLAELLVLN YGTHVTTSVD AGAALIQEDH LRASFLQDSQ SSRSAVTASA
   241  GLAFQNTVNF KFEENYTSQN VLTKSYLSNR TNSRVQSIGG VPFYPGITLQ AWQQGITNHL
   301  VAIDRSGLPL HFFINPNMLP DLPGPLVKKV SKTVETAVKR YYTFNTYPGC TDLNSPNFNF
   361  QANTDDGSCE GKMTNFSFGG VYQECTQLSG NRDVLLCQKL EQKNPLTGDF SCPSGYSPVH
   421  LLSQIHEEGY NHLECHRKCT LLVFCKTVCE DVFQVAKAEF RAFWCVASSQ VPENSGLLFG
   481  GLFSSKSINP MTNAQSCPAG YFPLRLFENL KVCVSQDYEL GSRFAVPFGG FFSCTVGNPL
   541  VDPAISRDLG APSLKKCPGG FSQHPALISD GCQVSYCVKS GLFTGGSLPP ARLPPFTRPP
   601  LMSQAATNTV IVTNSENARS WIKDSQTHQW RLGEPIELRR AMNVIHGDGG GLSGGAAAGV
   661  TVGVTTILAV VITLAIYGTR KFKKKAYQAI EERQSLVPGT AATGDTTYQE QGQSPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPEG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
194 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 194 nTPM
  • appendix: 106 nTPM
  • lymph node: 90 nTPM
  • tonsil: 70 nTPM
  • small intestine: 50 nTPM
  • rectum: 41 nTPM

Single-cell type

  • kupffer cells: 582 nCPM
  • monocytes: 371 nCPM
  • pdcs: 266 nCPM
  • macrophages: 195 nCPM
  • cdc: 121 nCPM
  • hofbauer cells: 100 nCPM

Immune cell

  • classical monocyte: 289 nTPM
  • non-classical monocyte: 246 nTPM
  • total PBMC: 214 nTPM
  • intermediate monocyte: 209 nTPM
  • plasmacytoid DC: 205 nTPM
  • myeloid DC: 144 nTPM

Brain region

  • thalamus: 9.2 nTPM
  • white matter: 9.1 nTPM
  • choroid plexus: 7.8 nTPM
  • medulla oblongata: 7.7 nTPM
  • spinal cord: 7 nTPM
  • pons: 6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MPEG1.

Disease | AllUniProt

Conditions MPEG1 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 148 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0
gnomAD missense Z
-0.05
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPEG1 as an antibody target. Whether an autoantibody or antibody against MPEG1 could matter depends on whether native MPEG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPEG1 is annotated as secreted, so native MPEG1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MPEG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MPEG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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