Seroatlas · Human Serome Atlas

MPC2

Mitochondrial pyruvate carrier 2

Also known as: BRP44, DKFZP564B167, MPC2_HUMAN, SLC54A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95563
Gene: MPC2
Ensembl: ENSG00000143158
Chromosome: 1
Canonical length: 127 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>O95563|MPC2
     1  MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW GLVCAGLADM
    61  ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN FFVGAAGASQ LFRIWRYNQE
   121  LKAKAHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 142 nTPM

Expression across tissuesHPA

Tissue

liver: 142 nTPM
testis: 119 nTPM
skeletal muscle: 96 nTPM
heart muscle: 78 nTPM
kidney: 78 nTPM
stomach: 66 nTPM

Single-cell type

late spermatids: 8,599 nCPM
early spermatids: 2,283 nCPM
late primary spermatocytes: 2,120 nCPM
parietal cells: 948 nCPM
hepatocytes: 796 nCPM
cytotrophoblasts: 627 nCPM

Immune cell

basophil: 95 nTPM
eosinophil: 93 nTPM
total PBMC: 84 nTPM
T-reg: 82 nTPM
neutrophil: 62 nTPM
myeloid DC: 59 nTPM

Brain region

cerebral cortex: 48 nTPM
basal ganglia: 45 nTPM
hypothalamus: 43 nTPM
thalamus: 43 nTPM
choroid plexus: 42 nTPM
white matter: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.64
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

inner mitochondrial membrane protein complex
mitochondrial inner membrane
mitochondrion
nucleus
mitochondrial pyruvate carrier complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MPC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPC2 as an antibody target. Whether an autoantibody or antibody against MPC2 could matter depends on whether native MPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...