Seroatlas · Human Serome Atlas

MPC1L

Mitochondrial pyruvate carrier 1-like protein

Also known as: MPC1L_HUMAN, SLC54A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DKB6
Gene
MPC1L
Ensembl
ENSG00000238205
Chromosome
X
Canonical length
136 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>P0DKB6|MPC1L
     1  MARMAVLWRK MRDNFQSKEF REYVSSTHFW GPAFSWGLPL AAFKDMKASP EIISGRMTTA
    61  LILYSAIFMR FAYRVQPRNL LLMACHCTNV MAQSVQASRY LLYYYGGGGA EAKARDPPAT
   121  AAAATSPGSQ PPKQAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPC1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late spermatids: 578 nCPM
  • early spermatids: 176 nCPM
  • late primary spermatocytes: 109 nCPM
  • oocytes: 65 nCPM
  • undifferentiated spermatogonia: 12 nCPM
  • early primary spermatocytes: 8.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.4 nTPM
  • cerebral cortex: 0.3 nTPM
  • thalamus: 0.3 nTPM
  • medulla oblongata: 0.2 nTPM
  • pons: 0.2 nTPM
  • white matter: 0.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPC1L as an antibody target. Whether an autoantibody or antibody against MPC1L could matter depends on whether native MPC1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPC1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPC1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MPC1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...