Seroatlas · Human Serome Atlas

MOSPD3

Motile sperm domain-containing protein 3

Also known as: CDS3, MSPD3_HUMAN, NET30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75425
Gene: MOSPD3
Ensembl: ENSG00000106330
Chromosome: 7
Canonical length: 235 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>O75425|MOSPD3
     1  MRRGAPQDQE LVGPGPPGRG SRGAPPPLGP VVPVLVFPPD LVFRADQRSG PRQLLTLYNP
    61  TGTALRFRVL CTAPAKYTVF DAEGYVKPQS CIDIVIRHVA PIPSHYDVQD RFRIELSEEG
   121  AEGRVVGRKD ITSILRAPAY PLELQGQPDP APRPGPPAGT PPPTARHFQE HPRQQLATSS
   181  FLLFLLTGIV SVAFLLLPLP DELGSQLPQV LHVSLGQKLV AAYVLGLLTM VFLRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOSPD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
skin: 41 nTPM
liver: 39 nTPM
adrenal gland: 36 nTPM
esophagus: 33 nTPM
kidney: 23 nTPM

Single-cell type

late spermatids: 2,548 nCPM
early spermatids: 378 nCPM
esophageal apical cells: 194 nCPM
late primary spermatocytes: 97 nCPM
esophageal suprabasal cells: 86 nCPM
parietal cells: 50 nCPM

Immune cell

T-reg: 57 nTPM
eosinophil: 40 nTPM
basophil: 39 nTPM
NK-cell: 38 nTPM
MAIT T-cell: 37 nTPM
memory CD8 T-cell: 37 nTPM

Brain region

medulla oblongata: 24 nTPM
amygdala: 22 nTPM
thalamus: 21 nTPM
basal ganglia: 20 nTPM
pons: 20 nTPM
hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

heart development

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOSPD3 as an antibody target. Whether an autoantibody or antibody against MOSPD3 could matter depends on whether native MOSPD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOSPD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOSPD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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