Seroatlas · Human Serome Atlas

MOSPD1

Motile sperm domain-containing protein 1

Also known as: dJ473B4, MSPD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJG1
Gene: MOSPD1
Ensembl: ENSG00000101928
Chromosome: X
Canonical length: 213 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9UJG1|MOSPD1
     1  MHQQKRQPEL VEGNLPVFVF PTELIFYADD QSTHKQVLTL YNPYEFALKF KVLCTTPNKY
    61  VVVDAAGAVK PQCCVDIVIR HRDVRSCHYG VIDKFRLQVS EQSQRKALGR KEVVATLLPS
   121  AKEQQKEEEE KRLKEHLTES LFFEQSFQPE NRAVSSGPSL LTVFLGVVCI AALMLPTLGD
   181  VESLVPLYLH LSVNQKLVAA YILGLITMAI LRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOSPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 25 nTPM
choroid plexus: 21 nTPM
skeletal muscle: 20 nTPM
heart muscle: 19 nTPM
endometrium: 15 nTPM
bone marrow: 15 nTPM

Single-cell type

esophageal apical cells: 273 nCPM
fallopian tube ciliated cells: 166 nCPM
late spermatids: 162 nCPM
early spermatids: 129 nCPM
endometrial ciliated cells: 108 nCPM
late primary spermatocytes: 96 nCPM

Immune cell

T-reg: 12 nTPM
eosinophil: 11 nTPM
MAIT T-cell: 7.9 nTPM
naive CD4 T-cell: 7.7 nTPM
naive CD8 T-cell: 7.7 nTPM
memory CD4 T-cell: 6.9 nTPM

Brain region

choroid plexus: 21 nTPM
medulla oblongata: 5.1 nTPM
cerebral cortex: 4.5 nTPM
cerebellum: 4.2 nTPM
hypothalamus: 4.1 nTPM
pons: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.92
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOSPD1 as an antibody target. Whether an autoantibody or antibody against MOSPD1 could matter depends on whether native MOSPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOSPD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOSPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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