Seroatlas · Human Serome Atlas

MORN5

MORN repeat-containing protein 5

Also known as: C9orf113, C9orf18, FLJ46909, MORN5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VZ52
Gene
MORN5
Ensembl
ENSG00000185681
Chromosome
9
Canonical length
161 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q5VZ52|MORN5
     1  MEYTGSKYIG EYVDGRMEGK AKYILPTETI YVGEMKDGMF HGEGTLYFPS GSQYDAIWEN
    61  GLAIKGTYTF SDGLHYDEKN WHYCDGYDRR FYTEILNGLK PAGMAQLTNM DPPRKIPKGY
   121  YDCGDGFYNP VTRVVKDYRN RFLRNADDDE HEWITRTCRK G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 104 nTPM
  • testis: 78 nTPM
  • choroid plexus: 77 nTPM
  • colon: 24 nTPM
  • smooth muscle: 16 nTPM
  • basal ganglia: 9.8 nTPM

Single-cell type

  • late spermatids: 997 nCPM
  • late primary spermatocytes: 573 nCPM
  • respiratory ciliated cells: 571 nCPM
  • fallopian tube ciliated cells: 539 nCPM
  • early spermatids: 440 nCPM
  • epididymal efferent duct ciliated cells: 373 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • midbrain: 19 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 9 nTPM
  • white matter: 7 nTPM
  • hypothalamus: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0
gnomAD missense Z
0.41
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORN5 as an antibody target. Whether an autoantibody or antibody against MORN5 could matter depends on whether native MORN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MORN5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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