Seroatlas · Human Serome Atlas

MORN2

MORN repeat-containing protein 2

Also known as: MOPT, MORN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q502X0
Gene
MORN2
Ensembl
ENSG00000188010
Chromosome
2
Canonical length
79 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>Q502X0|MORN2
     1  MNGFGRLEHF SGAVYEGQFK DNMFHGLGTY TFPNGAKYTG NFNENRVEGE GEYTDIQGLE
    61  WSGNFHFTAA PDLKLKLHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
182 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 182 nTPM
  • testis: 170 nTPM
  • fallopian tube: 87 nTPM
  • parathyroid gland: 73 nTPM
  • kidney: 70 nTPM
  • epididymis: 67 nTPM

Single-cell type

  • late spermatids: 6,209 nCPM
  • early spermatids: 2,038 nCPM
  • late primary spermatocytes: 1,510 nCPM
  • respiratory ciliated cells: 898 nCPM
  • fallopian tube ciliated cells: 870 nCPM
  • endometrial ciliated cells: 743 nCPM

Immune cell

  • classical monocyte: 8.4 nTPM
  • intermediate monocyte: 6.9 nTPM
  • myeloid DC: 6 nTPM
  • non-classical monocyte: 5.6 nTPM
  • T-reg: 4.1 nTPM
  • total PBMC: 3.8 nTPM

Brain region

  • choroid plexus: 59 nTPM
  • midbrain: 26 nTPM
  • medulla oblongata: 25 nTPM
  • hypothalamus: 22 nTPM
  • basal ganglia: 22 nTPM
  • white matter: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0.15
gnomAD missense Z
0.06
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORN2 as an antibody target. Whether an autoantibody or antibody against MORN2 could matter depends on whether native MORN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MORN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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