Seroatlas · Human Serome Atlas

MORN1

MORN repeat-containing protein 1

Also known as: FLJ13941, MORN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T089
Gene: MORN1
Ensembl: ENSG00000116151
Chromosome: 1
Canonical length: 497 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

No narrative summary is available for MORN1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

497 residues, UniProt reviewed canonical sequence.

>Q5T089|MORN1
     1  MAAAGEGTPS SRGPRRDPPR RPPRNGYGVY VYPNSFFRYE GEWKAGRKHG HGKLLFKDGS
    61  YYEGAFVDGE ITGEGRRHWA WSGDTFSGQF VLGEPQGYGV MEYKAGGCYE GEVSHGMREG
   121  HGFLVDRDGQ VYQGSFHDNK RHGPGQMLFQ NGDKYDGDWV RDRRQGHGVL RCADGSTYKG
   181  QWHSDVFSGL GSMAHCSGVT YYGLWINGHP AEQATRIVIL GPEVMEVAQG SPFSVNVQLL
   241  QDHGEIAKSE SGRVLQISAG VRYVQLSAYS EVNFFKVDRD NQETLIQTPF GFECIPYPVS
   301  SPAAGVPGPR AAKGGAEADV PLPRGDLELH LGALHGQEDT PGGLLARGHA PHCPGACQRV
   361  EQGCAEFTDV LLGPPPPGYH PFLFLDSLHK KAGGRSRGGL HPRGTPPTAQ EPPGGSRPEG
   421  RATEEQAAAA HLGEYVLMIR DVTTPPFLGR RLPPAFKHLR VVAKRAGQPP HVLEEGPEAS
   481  SSWQAAHSCT PEPPAPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
testis: 15 nTPM
thyroid gland: 13 nTPM
fallopian tube: 13 nTPM
ovary: 9.8 nTPM
pituitary gland: 9.7 nTPM

Single-cell type

respiratory ciliated cells: 148 nCPM
fallopian tube ciliated cells: 97 nCPM
ependymal cells: 84 nCPM
endometrial ciliated cells: 66 nCPM
epididymal efferent duct ciliated cells: 66 nCPM
late primary spermatocytes: 62 nCPM

Immune cell

non-classical monocyte: 2 nTPM
neutrophil: 1.7 nTPM
plasmacytoid DC: 1.6 nTPM
naive CD4 T-cell: 0.9 nTPM
naive B-cell: 0.8 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

cerebellum: 33 nTPM
choroid plexus: 21 nTPM
midbrain: 15 nTPM
medulla oblongata: 13 nTPM
cerebral cortex: 12 nTPM
spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MORN1 as an antibody target. Whether an autoantibody or antibody against MORN1 could matter depends on whether native MORN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MORN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MORN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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