MORC4

Protein identityUniProt · HPA

UniProt accession

Q8TE76

Gene

MORC4

Ensembl

ENSG00000133131

Chromosome

X

Canonical length

937 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

937 residues, UniProt reviewed canonical sequence.

>Q8TE76|MORC4
     1  MLLYRGAPAG PGAPGCGLAR PGGGPQAFGI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN
    61  AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQCPIGV
   121  FGNGFKSGSM RLGKDALVFT KNGGTLTVGL LSQTYLECVQ AQAVIVPIVP FNQQNKKMII
   181  TEDSLPSLEA ILNYSIFNRE NDLLAQFDAI PGKKGTRVLI WNIRRNKNGK SELDFDTDQY
   241  DILVSDFDTE EKMTGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA
   301  NVEYDTYKPT FTNKQVRITF GFSCKNSNQF GIMMYHNNRL IKSFEKVGCQ VKPTRGEGVG
   361  VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNAYW KEKTSQDNFE TSTVARPIPK
   421  VPDQTWVQCD ECLKWRKLPG KIDPSMLPAR WFCYYNSHPK YRRCSVPEEQ ELTDEDLCLS
   481  KAKKQEQTVE EKKKMPMENE NHQVFSNPPK ILTVQEMAGL NNKTIGYEGI HSPSVLPSGG
   541  EESRSPSLQL KPLDSSVLQF SSKYKWILGE EPVEKRRRLQ NEMTTPSLDY SMPAPYRRVE
   601  APVAYPEGEN SHDKSSSERS TPPYLFPEYP EASKNTGQNR EVSILYPGAK DQRQGSLLPE
   661  ELEDQMPRLV AEESNRGSTT INKEEVNKGP FVAVVGVAKG VRDSGAPIQL IPFNREELAE
   721  RRKAVESWNP VPYSVASAAI PAAAIGEKAR GYEESEGHNT PKLKNQRELE ELKRTTEKLE
   781  RVLAERNLFQ QKVEELEQER NHWQSEFKKV QHELVIYSTQ EAEGLYWSKK HMGYRQAEFQ
   841  ILKAELERTK EEKQELKEKL KETETHLEML QKAQVSYRTP EGDDLERALA KLTRLRIHVS
   901  YLLTSVLPHL ELREIGYDSE QVDGILYTVL EANHILD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MORC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

75 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

1.36

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• ATP hydrolysis activity
• histone H3K4me3 reader activity
• zinc ion binding

Cellular components

• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, CW-type
• Histidine kinase/HSP90-like ATPase superfamily
• Morc, S5 domain 2-like
• MICRORCHIDIA ATPase family
• CW-type Zinc Finger
• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
• Morc6 ribosomal protein S5 domain 2-like

KeywordsUniProt

• Coiled coil
• Metal-binding
• Nucleus
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of MORC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• STAT3