Seroatlas · Human Serome Atlas

MOK

MAPK/MAK/MRK overlapping kinase

Also known as: MOK_HUMAN, RAGE, RAGE1, STK30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQ07
Gene: MOK
Ensembl: ENSG00000080823
Chromosome: 14
Canonical length: 419 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q9UQ07|MOK
     1  MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH
    61  PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH
   121  RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT
   181  YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP
   241  FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR
   301  KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL
   361  SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

retina: 117 nTPM
testis: 52 nTPM
choroid plexus: 36 nTPM
fallopian tube: 20 nTPM
pituitary gland: 19 nTPM
thyroid gland: 14 nTPM

Single-cell type

rod photoreceptor cells: 615 nCPM
ependymal cells: 550 nCPM
respiratory ciliated cells: 527 nCPM
choroid plexus epithelial cells: 433 nCPM
endometrial ciliated cells: 432 nCPM
late primary spermatocytes: 291 nCPM

Immune cell

NK-cell: 8.1 nTPM
myeloid DC: 3 nTPM
naive CD8 T-cell: 1.7 nTPM
memory CD8 T-cell: 1.4 nTPM
MAIT T-cell: 0.9 nTPM
total PBMC: 0.9 nTPM

Brain region

choroid plexus: 33 nTPM
cerebral cortex: 14 nTPM
midbrain: 12 nTPM
hippocampal formation: 12 nTPM
hypothalamus: 12 nTPM
medulla oblongata: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MOK.

Disease | ImmuneIEDB

Conditions an epitope on MOK was assayed in.

skin melanoma T cell
melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOK as an antibody target. Whether an autoantibody or antibody against MOK could matter depends on whether native MOK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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