MOG

Protein identityUniProt · HPA

UniProt accession

Q16653

Gene

MOG

Ensembl

ENSG00000204655

Chromosome

6

Canonical length

247 aa

Protein class

Disease related genes, Human disease related genes, Predicted membrane proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q16653|MOG
     1  MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN
    61  ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS
   121  DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY
   181  RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL
   241  EELRNPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

687 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MOG.

Disease | AllUniProt

Conditions MOG is implicated in, by any mechanism.

• Narcolepsy 7 (NRCLP7) MIM:614250

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Narcolepsy 7

Disease | ImmuneIEDB

Conditions an epitope on MOG was assayed in.

• multiple sclerosis B and T cell
• neuromyelitis optica B and T cell
• autoimmune disease of central nervous system T cell
• amyotrophic lateral sclerosis B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against MOG are reported. Each links to that disease's full target list.

• Neuromyelitis Optica 509
• Multiple Sclerosis 302
• Encephalitis 123
• Encephalomyelitis, Autoimmune, Experimental 94
• COVID-19 61
• Seizures 37
• Autoimmune Diseases of the Nervous System 30
• Neoplasm Recurrence, Local 30
• Hashimoto Disease 23
• Headache 13
• Epilepsy 11
• Lupus Erythematosus, Systemic 9
• Brain Diseases 6
• Peripheral Nervous System Diseases 5
• Limbic Encephalitis 4
• HIV Infections 3
• Pain 3
• Sjogren's Syndrome 3

Showing 18 of 49 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for MOG from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.64

gnomAD pLI

0.14

gnomAD missense Z

0.51

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• central nervous system development
• regulation of cytokine production
• T cell receptor signaling pathway

Molecular functions

• signaling receptor binding
• virus receptor activity

Cellular components

• external side of plasma membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• BTN/MOG-like
• Immunoglobulin V-set domain
• Myelin-oligodendrocyte glycoprotein

KeywordsUniProt

• Cell adhesion
• Cell membrane
• Disulfide bond
• Glycoprotein
• Host cell receptor for virus entry
• Host-virus interaction
• Immunoglobulin domain
• Membrane
• Receptor
• Signal
• Transmembrane
• Transmembrane helix