Seroatlas · Human Serome Atlas

MOBP

Myelin-associated oligodendrocyte basic protein

Also known as: MOBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13875
Gene: MOBP
Ensembl: ENSG00000168314
Chromosome: 3
Canonical length: 183 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytoplasmic bodies

OverviewNCBI Gene

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion and perinuclear region of cytoplasm. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q13875|MOBP
     1  MSQKPAKEGP RLSKNQKYSE HFSIHCCPPF TFLNSKKEIV DRKYSICKSG CFYQKKEEDW
    61  ICCACQKTRT SRRAKSPQRP KQQPAAPPAV VRAPAKPRSP PRSERQPRSP PRSERQPRSP
   121  PRSERQPRSP PRSERQPRPR PEVRPPPAKQ RPPQKSKQQP RSSPLRGPGA SRGGSPVKAS
   181  RFW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 874 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 874 nTPM
midbrain: 336 nTPM
hippocampal formation: 202 nTPM
hypothalamus: 139 nTPM
amygdala: 136 nTPM
basal ganglia: 105 nTPM

Single-cell type

oligodendrocytes: 1,900 nCPM
late spermatids: 153 nCPM
early spermatids: 110 nCPM
late primary spermatocytes: 109 nCPM
granulosa cells: 58 nCPM
platelets: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1,773 nTPM
medulla oblongata: 1,626 nTPM
pons: 1,277 nTPM
spinal cord: 1,048 nTPM
basal ganglia: 954 nTPM
thalamus: 931 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MOBP.

Disease | ImmuneIEDB

Conditions an epitope on MOBP was assayed in.

multiple sclerosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0.55
gnomAD missense Z: 0.97
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nervous system development

Molecular functions

structural constituent of myelin sheath

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOBP as an antibody target. Whether an autoantibody or antibody against MOBP could matter depends on whether native MOBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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