MNDA

Protein identityUniProt · HPA

UniProt accession

P41218

Gene

MNDA

Ensembl

ENSG00000163563

Chromosome

1

Canonical length

407 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Nucleoli rim,Vesicles,Cytosol

OverviewNCBI Gene

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>P41218|MNDA
     1  MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA
    61  CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN
   121  KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS
   181  STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV
   241  ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII
   301  EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK
   361  CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MNDA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

277 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MNDA.

Disease | ImmuneIEDB

Conditions an epitope on MNDA was assayed in.

• rheumatoid arthritis B cell
• Sjogren's syndrome B cell
• multiple sclerosis B cell
• systemic lupus erythematosus B cell
• type 1 diabetes mellitus B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0

gnomAD missense Z

-0.99

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of innate immune response
• B cell receptor signaling pathway
• cellular defense response
• cellular response to interferon-beta
• DNA damage response
• negative regulation of B cell proliferation
• positive regulation of apoptotic process

Molecular functions

• double-stranded DNA binding

Cellular components

• azurophil granule lumen
• cytosol
• extracellular exosome
• extracellular region
• ficolin-1-rich granule lumen
• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• DAPIN domain
• HIN-200/IF120x
• Death-like domain superfamily
• Nucleic acid-binding, OB-fold
• HIN-200 family
• PAAD/DAPIN/Pyrin domain
• HIN-200/IF120x domain

KeywordsUniProt

• Activator
• Cytoplasm
• DNA-binding
• Nucleus
• Repressor
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of MNDA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NSD3