Seroatlas · Human Serome Atlas

MMEL1

Membrane metallo-endopeptidase-like 1

Also known as: MMEL1_HUMAN, MMEL2, NEPII, NL1, NL2, SEP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q495T6
Gene: MMEL1
Ensembl: ENSG00000142606
Chromosome: 1
Canonical length: 779 aa
Protein class: Enzymes, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

779 residues, UniProt reviewed canonical sequence.

>Q495T6|MMEL1
     1  MGKSEGPVGM VESAGRAGQK RPGFLEGGLL LLLLLVTAAL VALGVLYADR RGKQLPRLAS
    61  RLCFLQEERT FVKRKPRGIP EAQEVSEVCT TPGCVIAAAR ILQNMDPTTE PCDDFYQFAC
   121  GGWLRRHVIP ETNSRYSIFD VLRDELEVIL KAVLENSTAK DRPAVEKART LYRSCMNQSV
   181  IEKRGSQPLL DILEVVGGWP VAMDRWNETV GLEWELERQL ALMNSQFNRR VLIDLFIWND
   241  DQNSSRHIIY IDQPTLGMPS REYYFNGGSN RKVREAYLQF MVSVATLLRE DANLPRDSCL
   301  VQEDMVQVLE LETQLAKATV PQEERHDVIA LYHRMGLEEL QSQFGLKGFN WTLFIQTVLS
   361  SVKIKLLPDE EVVVYGIPYL QNLENIIDTY SARTIQNYLV WRLVLDRIGS LSQRFKDTRV
   421  NYRKALFGTM VEEVRWRECV GYVNSNMENA VGSLYVREAF PGDSKSMVRE LIDKVRTVFV
   481  ETLDELGWMD EESKKKAQEK AMSIREQIGH PDYILEEMNR RLDEEYSNLN FSEDLYFENS
   541  LQNLKVGAQR SLRKLREKVD PNLWIIGAAV VNAFYSPNRN QIVFPAGILQ PPFFSKEQPQ
   601  ALNFGGIGMV IGHEITHGFD DNGRNFDKNG NMMDWWSNFS TQHFREQSEC MIYQYGNYSW
   661  DLADEQNVNG FNTLGENIAD NGGVRQAYKA YLKWMAEGGK DQQLPGLDLT HEQLFFINYA
   721  QVWCGSYRPE FAIQSIKTDV HSPLKYRVLG SLQNLAAFAD TFHCARGTPM HPKERCRVW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
stomach: 7.8 nTPM
prostate: 6.3 nTPM
basal ganglia: 5.5 nTPM
esophagus: 4.7 nTPM
hypothalamus: 4.4 nTPM

Single-cell type

early spermatids: 23 nCPM
gastric chief cells: 21 nCPM
endometrial secretory cells: 11 nCPM
ependymal cells: 9.7 nCPM
late spermatids: 8.4 nCPM
late primary spermatocytes: 5.4 nCPM

Immune cell

basophil: 5.9 nTPM
eosinophil: 4.7 nTPM
T-reg: 4.2 nTPM
non-classical monocyte: 3.7 nTPM
naive CD4 T-cell: 2.7 nTPM
intermediate monocyte: 2.6 nTPM

Brain region

medulla oblongata: 1.6 nTPM
midbrain: 1.6 nTPM
hypothalamus: 1 nTPM
pons: 1 nTPM
spinal cord: 0.9 nTPM
thalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMEL1 as an antibody target. Whether an autoantibody or antibody against MMEL1 could matter depends on whether native MMEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMEL1 is annotated as secreted, so native MMEL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MMEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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