Seroatlas · Human Serome Atlas

MLYCD

Malonyl-CoA decarboxylase, mitochondrial

Also known as: DCMC_HUMAN, hMCD, MCD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95822
Gene
MLYCD
Ensembl
ENSG00000103150
Chromosome
16
Canonical length
493 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>O95822|MLYCD
     1  MRGFGPGLTA RRLLPLRLPP RPPGPRLASG QAAGALERAM DELLRRAVPP TPAYELREKT
    61  PAPAEGQCAD FVSFYGGLAE TAQRAELLGR LARGFGVDHG QVAEQSAGVL HLRQQQREAA
   121  VLLQAEDRLR YALVPRYRGL FHHISKLDGG VRFLVQLRAD LLEAQALKLV EGPDVREMNG
   181  VLKGMLSEWF SSGFLNLERV TWHSPCEVLQ KISEAEAVHP VKNWMDMKRR VGPYRRCYFF
   241  SHCSTPGEPL VVLHVALTGD ISSNIQAIVK EHPPSETEEK NKITAAIFYS ISLTQQGLQG
   301  VELGTFLIKR VVKELQREFP HLGVFSSLSP IPGFTKWLLG LLNSQTKEHG RNELFTDSEC
   361  KEISEITGGP INETLKLLLS SSEWVQSEKL VRALQTPLMR LCAWYLYGEK HRGYALNPVA
   421  NFHLQNGAVL WRINWMADVS LRGITGSCGL MANYRYFLEE TGPNSTSYLG SKIIKASEQV
   481  LSLVAQFQKN SKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLYCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 20 nTPM
  • heart muscle: 8.5 nTPM
  • liver: 5.4 nTPM
  • skeletal muscle: 5.3 nTPM
  • pancreas: 4.8 nTPM
  • choroid plexus: 3 nTPM

Single-cell type

  • choroid plexus epithelial cells: 33 nCPM
  • astrocytes: 31 nCPM
  • bergmann glia: 31 nCPM
  • myonuclei: 30 nCPM
  • cone photoreceptor cells: 29 nCPM
  • oligodendrocytes: 21 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • eosinophil: 0.5 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • thalamus: 11 nTPM
  • choroid plexus: 10 nTPM
  • medulla oblongata: 10 nTPM
  • midbrain: 9.8 nTPM
  • white matter: 9.6 nTPM
  • basal ganglia: 9.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MLYCD.

Disease | AllUniProt

Conditions MLYCD is implicated in, by any mechanism.

  • Malonyl-CoA decarboxylase deficiency (MLYCD deficiency) MIM:248360

Disease | GeneticClinVar

69 pathogenic / likely-pathogenic of 755 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
-1.76
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Malonyl-CoA decarboxylase, C-terminal
  • Malonyl-CoA decarboxylase, N-terminal
  • Malonyl-CoA decarboxylase, N-terminal domain superfamily
  • Malonyl-CoA decarboxylase
  • Malonyl-CoA decarboxylase, C-terminal catalytic domain superfamily
  • Malonyl-CoA decarboxylase C-terminal domain
  • Malonyl-CoA decarboxylase N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLYCD as an antibody target. Whether an autoantibody or antibody against MLYCD could matter depends on whether native MLYCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLYCD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLYCD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLYCD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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