MLXIP
MLX-interacting protein
Also known as: bHLHe36, KIAA0867, MIR, MLXIP_HUMAN, MONDOA
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9HAP2
- Gene
- MLXIP
- Ensembl
- ENSG00000175727
- Chromosome
- 12
- Canonical length
- 919 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
Canonical amino-acid sequenceUniProt
919 residues, UniProt reviewed canonical sequence.
>Q9HAP2|MLXIP
1 MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA RAHASAAPPP
61 PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD TVNKQTCQTY SFGKTSSCHL
121 SIDASLTKLF ECMTLAYSGK LVSPKWKNFK GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN
181 PVCHFVTPLD GSVDVDEHRR PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED
241 LSSLVQDDDM LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP
301 REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS ASAPVPDPNN
361 PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE HTSRTEDPFI QPTDFGPSEP
421 PLSVPQPFLP VFTMPLLSPS PAPPPISPVL PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA
481 PSVITHTASA TLTHDAPATT FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH
541 PKPVSLTGGR PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML
601 ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP STAQDPLGKG
661 EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS PQNNCSGKSD PKNVAALKNR
721 QMKHISAEQK RRFNIKMCFD MLNSLISNNS KLTSHAITLQ KTVEYITKLQ QERGQMQEEA
781 RRLREEIEEL NATIISCQQL LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII
841 IKPLFESFKG MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ
901 LPEQASKAVT RIGKRLGESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MLXIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 123 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 123 nTPM
- colon: 71 nTPM
- pancreas: 59 nTPM
- ovary: 45 nTPM
- urinary bladder: 45 nTPM
- rectum: 42 nTPM
Single-cell type
- podocytes: 119 nCPM
- microglia: 106 nCPM
- proximal tubule cells: 87 nCPM
- enteric stem cells: 86 nCPM
- loop of henle epithelial cells: 85 nCPM
- pancreatic acinar cells: 83 nCPM
Immune cell
- classical monocyte: 3.7 nTPM
- naive CD8 T-cell: 3.2 nTPM
- plasmacytoid DC: 3 nTPM
- neutrophil: 2.9 nTPM
- naive CD4 T-cell: 2.7 nTPM
- basophil: 2.4 nTPM
Brain region
- cerebellum: 41 nTPM
- white matter: 39 nTPM
- cerebral cortex: 39 nTPM
- pons: 35 nTPM
- medulla oblongata: 35 nTPM
- thalamus: 35 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.29
- gnomAD pLI
- 0.99
- gnomAD missense Z
- 2.25
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- protein dimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MLXIP as an antibody target. Whether an autoantibody or antibody against MLXIP could matter depends on whether native MLXIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MLXIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MLXIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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