MLX
Max-like protein X
Also known as: bHLHd13, MAD7, MLX_HUMAN, MXD7, TCFL4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UH92
- Gene
- MLX
- Ensembl
- ENSG00000108788
- Chromosome
- 17
- Canonical length
- 298 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear membrane,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
298 residues, UniProt reviewed canonical sequence.
>Q9UH92|MLX
1 MTEPGASPED PWVKASPVGA HAGEGRAGRA RARRGAGRRG ASLLSPKSPT LSVPRGCRED
61 SSHPACAKVE YAYSDNSLDP GLFVESTRKG SVVSRANSIG STSASSVPNT DDEDSDYHQE
121 AYKESYKDRR RRAHTQAEQK RRDAIKRGYD DLQTIVPTCQ QQDFSIGSQK LSKAIVLQKT
181 IDYIQFLHKE KKKQEEEVST LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN
241 VFQGIMDSLF QSFNASISVA SFQELSACVF SWIEEHCKPQ TLREIVIGVL HQLKNQLYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MLX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 81 nTPM
Expression across tissuesHPA
Tissue
- tongue: 81 nTPM
- skeletal muscle: 71 nTPM
- heart muscle: 54 nTPM
- liver: 48 nTPM
- duodenum: 45 nTPM
- small intestine: 40 nTPM
Single-cell type
- breast lactating cells: 180 nCPM
- esophageal apical cells: 161 nCPM
- enterocytes: 121 nCPM
- colonocytes: 94 nCPM
- esophageal suprabasal cells: 94 nCPM
- alveolar cells type 1: 89 nCPM
Immune cell
- eosinophil: 92 nTPM
- non-classical monocyte: 91 nTPM
- neutrophil: 84 nTPM
- intermediate monocyte: 80 nTPM
- total PBMC: 69 nTPM
- myeloid DC: 67 nTPM
Brain region
- choroid plexus: 16 nTPM
- white matter: 12 nTPM
- cerebral cortex: 11 nTPM
- hypothalamus: 11 nTPM
- medulla oblongata: 11 nTPM
- spinal cord: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.67
- gnomAD pLI
- 0.11
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- -0.25
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- protein heterodimerization activity
- protein homodimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MLX as an antibody target. Whether an autoantibody or antibody against MLX could matter depends on whether native MLX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MLX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MLX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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