MLNR
Motilin receptor
Also known as: GPR38, MTLR_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43193
- Gene
- MLNR
- Ensembl
- ENSG00000102539
- Chromosome
- 13
- Canonical length
- 412 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
Canonical amino-acid sequenceUniProt
412 residues, UniProt reviewed canonical sequence.
>O43193|MLNR
1 MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV VGVSGNVVTV
61 MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR SRPWVFGPLL CRLSLYVGEG
121 CTYATLLHMT ALSVERYLAI CRPLRARVLV TRRRVRALIA VLWAVALLSA GPFLFLVGVE
181 QDPGISVVPG LNGTARIASS PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA
241 QLGALRVMLW VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL
301 LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI NPILYNLISK
361 KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG YTETSANVKT MGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MLNR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 1.6 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 1.6 nTPM
- bone marrow: 1.2 nTPM
- stomach: 0.4 nTPM
- heart muscle: 0.1 nTPM
- kidney: 0.1 nTPM
- retina: 0.1 nTPM
Single-cell type
- neutrophil progenitors: 1.8 nCPM
- hematopoietic stem cells: 0.5 nCPM
- cardiomyocytes: 0.3 nCPM
- müller glia: 0.2 nCPM
- papillary tip epithelial cells: 0.2 nCPM
- differentiating spermatogonia: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 2 nTPM
- medulla oblongata: 1.8 nTPM
- thalamus: 1.7 nTPM
- pons: 1.6 nTPM
- white matter: 1.6 nTPM
- basal ganglia: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.16
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.62
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MLNR as an antibody target. Whether an autoantibody or antibody against MLNR could matter depends on whether native MLNR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MLNR is annotated at the cell surface, where native MLNR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MLNR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...